• 66 Citaten
20162020
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Persoonlijk profiel

Research profile

Femke Meijer is a PhD candidate in the Chemical Biology group under supervision of prof. Luc Brunsveld. Her project focusses on the identification of novel small molecule ligands for the selective modulation of nuclear receptors, especially for RORγt which plays an important role in several autoimmune diseases. The main interest is to target the recently discovered allosteric binding site of RORγt, which has many advantages in comparison to the common orthosteric site, in terms of selectivity and preventing competition issues. Femke uses a combination of medicinal chemistry, organic synthesis, computational biology and biochemical assays to gain insight into this topic.   

Academic background

Femke Meijer (1993) has studied Biomedical Engineering at the Eindhoven University of Technology (TU/e). After receiving her Bachelor degree in 2014, she continued with her Master in the Chemical Biology group of prof. Luc Brunsveld. During her Master’s graduation project, she worked on the design and synthesis of peptide-small molecule hybrids for the modulation of certain protein-protein interactions (PPIs) that are involved in Alzheimer’s disease. Additionally, she performed an internship at Imperial College London (in the research group of prof. Ed Tate), on the organic synthesis of photo-crosslinkable α-helix mimetics and testing their selectivity for inhibiting the p53/hDM2 interaction, which is an important target in cancer therapy. Femke received her Master degree cum laude in 2017.

Vingerafdruk Duik in de onderzoeksthema's waar Femke A. Meijer actief is. Deze onderwerplabels komen voort uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

  • 4 Vergelijkbare profielen
Cytoplasmic and Nuclear Receptors Medicijnen en Levenswetenschappen
Ligands Medicijnen en Levenswetenschappen
Retinoid X Receptors Medicijnen en Levenswetenschappen
Cystic Fibrosis Transmembrane Conductance Regulator Medicijnen en Levenswetenschappen
Retinoic Acid Receptors Medicijnen en Levenswetenschappen
Proteins Medicijnen en Levenswetenschappen
Isoxazoles Medicijnen en Levenswetenschappen
Alleles Medicijnen en Levenswetenschappen

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Onderzoeksoutput 2016 2020

  • 66 Citaten
  • 5 Tijdschriftartikel
  • 1 Artikel recenseren
10 Downloads (Pure)

Ligand-based design of allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists

Meijer, F. A., Doveston, R. G., de Vries, R. M. J. M., Vos, G. M., Vos, A. A. A., Leysen, S., Scheepstra, M., Ottmann, C., Milroy, L-G. & Brunsveld, L., 9 jan 2020, In : Journal of Medicinal Chemistry. 63, 1, blz. 241-259 19 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Retinoic Acid Receptors
Isoxazoles
Cytoplasmic and Nuclear Receptors
Ligands
Interleukin-17
5 Citaties (Scopus)
129 Downloads (Pure)

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 5 apr 2019, In : Molecular and Cellular Endocrinology. 485, blz. 20-34 15 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

Open Access
Bestand
Cytoplasmic and Nuclear Receptors
Allosteric Site
Ligands
Drug Discovery
Pathology
6 Citaties (Scopus)

Characterization of coding/noncoding variants for SHROOM3 in patients with CKD

Prokop, J. W., Ottmann, C., Chhetri, S. B., Florus, K. L., Ross, E. J., Sosonkina, N., Link, B. A., Freedman, B. I., Coppola, C. J., McDermott-Roe, C., Leysen, S. F. R., Milroy, L. G., Meijer, F. A., Geurts, A. M., Rauscher III, F. J., Ramaker, R., Flister, M. J., Jacob, H. J., Mendenhall, E. M., Lazar, J. & 1 anderen, Yeo, N. C., 23 feb 2018, In : Journal of the American Society of Nephrology. 29, May 2018, blz. 1525-1535

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Alleles
Gene Frequency
Molecular Biology
Transcription Factor 7-Like 2 Protein
Clustered Regularly Interspaced Short Palindromic Repeats
7 Citaties (Scopus)
24 Downloads (Pure)

Inhibition of 14-3-3/Tau by hybrid small-molecule peptides operating via two different binding modes

Andrei, S. A., Meijer, F. A., Neves, J., Brunsveld, L., Landrieu, I., Ottmann, C. & Milroy, L. G., 1 nov 2018, In : ACS Chemical Neuroscience. 9, 11, blz. 2639–2654

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Peptides
Molecules
Alzheimer Disease
Proteins
Drug Interactions
6 Citaties (Scopus)
90 Downloads (Pure)

Ligand dependent switch from RXR homo- to RXR-NURR1 heterodimerization

Scheepstra, M., Andrei, S. A., de Vries, R. M. J. M., Meijer, F. A., Ma, J-N., Burstein, E. S., Olsson, R., Ottmann, C., Milroy, L-G. & Brunsveld, L., 1 sep 2017, In : ACS Chemical Neuroscience. 8, 9, blz. 2065-2077 13 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Retinoid X Receptors
Cytoplasmic and Nuclear Receptors
Switches
Ligands
Proteins