Persoonlijk profiel
Research profile
Federica Eduati is Associate Professor in Systems Biology for Oncology at the Department of Biomedical Engineering. Her research aims to understand why patients respond differently to cancer therapies and to develop personalized treatment strategies through interpretable computational models. Her group integrates prior knowledge of regulatory mechanisms with experimental data from diverse modalities—including omics and imaging—and develops multiscale models with spatial resolution to study signaling dynamics and tumor–immune interactions. These models are trained and validated using data from public repositories, collaborators, and in-house experiments, including those generated through advanced droplet microfluidics. Her work contributes to the development of predictive, interpretable models for precision oncology.
Quote
I want to contribute to the improvement of cancer therapy, using systems approaches to gain important insights into the complexity of tumors.
Academic background
Federica Eduati received a BSc in Biomedical Engineering (2006) and a MSc in Bioengineering (2008) from the University of Padova, Italy (both cum laude). During her PhD research she worked in the field of systems biology using different computational modeling approaches in order to gain new insights into biological systems. Following her graduation in 2013, she became a postdoc (EMBL EIPOD, co-funded Marie Curie fellowship) at the European Molecular Biology Laboratory (EMBL), shared between the Systems Biomedicine group of Julio Saez-Rodriguez at EMBL-EBI (Cambridge, UK) and the microfluidics group of Christoph Merten at EMBL-HD (Heidelberg, Germany). Since 2018 she is assistant professor in the Computational Biology group at Eindhoven University of Technology (TU/e, The Netherlands), working on systems biology for (immuno-)oncology. In 2013, Federica was co-organizer of the NIEHS-NCATS-UNC DREAM Toxicogenetics Challenge (http://dreamchallenges.org/).
Expertise gerelateerd aan duurzame ontwikkelingsdoelstellingen van de VN
In 2015 stemden de VN-lidstaten in met 17 wereldwijde duurzame ontwikkelingsdoelstellingen (Sustainable Development Goals, SDG's) om armoede te beëindigen, de planeet te beschermen en voor iedereen welvaart te garanderen. Het werk van deze persoon draagt bij aan de volgende duurzame ontwikkelingsdoelstelling(en):
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SDG 3 – Goede gezondheid en welzijn
Vingerafdruk
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
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Mathematically mapping the network of cells in the tumor microenvironment
van Santvoort, M., Lapuente Santana, O., Zopoglou, M., Zackl, C., Finotello, F., van der Hoorn, P. & Eduati, F. (Corresponding author), 24 feb. 2025, In: Cell Reports Methods. 5, 2, 21 blz., 100985.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand2 !!Link opens in a new tab Citaten (Scopus)51 Downloads (Pure) -
Integrating histopathology and transcriptomics for spatial tumor microenvironment profiling in a melanoma case study
Lapuente-Santana, Ó., Kant, J. & Eduati, F. (Corresponding author), 7 nov. 2024, In: npj Precision Oncology. 8, 1, 15 blz., 254.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand5 !!Link opens in a new tab Citaten (Scopus)22 Downloads (Pure) -
Agent-based modeling of the prostate tumor microenvironment uncovers spatial tumor growth constraints and immunomodulatory properties
van Genderen, M. N. G., Kneppers, J., Zaalberg, A., Bekers, E. M., Bergman, A. M. (Corresponding author), Zwart, W. (Corresponding author) & Eduati, F. (Corresponding author), 21 feb. 2024, In: npj Systems Biology and Applications. 10, 1, 13 blz., 20.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand6 !!Link opens in a new tab Citaten (Scopus)68 Downloads (Pure) -
Interpretable systems biomarkers predict response to immune-checkpoint inhibitors
Lapuente-Santana, Ó., van Genderen, M., Hilbers, P. A. J., Finotello, F. & Eduati, F. (Corresponding author), 13 aug. 2021, In: Patterns. 2, 8, 100293.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand107 !!Link opens in a new tab Citaten (Scopus)184 Downloads (Pure) -
Patient-specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies
Eduati, F., Jaaks, P., Wappler, J., Cramer, T., Merten, C. A., Garnett, M. J. & Saez-Rodriguez, J. (Corresponding author), feb. 2020, In: Molecular Systems Biology. 16, 2, 13 blz., e8664.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand52 !!Link opens in a new tab Citaten (Scopus)229 Downloads (Pure)
Datasets
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Data and code for "A microfluidics platform for combinatorial drug screening on cancer biopsies"
Eduati, F. (Bijdrager), Utharala, R. (Bijdrager), Madhavan, D. (Bijdrager), Neumann, U. P. (Bijdrager), Cramer, T. (Bijdrager), Saez-Rodriguez, J. (Bijdrager) & Merten, C. A. (Bijdrager), Zenodo, 17 mei 2018
DOI: 10.5281/zenodo.1248886, https://zenodo.org/record/1248886
Dataset
Cursussen
Knipsels
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Eindhoven University of Technology Researcher Details Research in Prostate Cancer (Exploring the Onset and Progression of Prostate Cancer through a Multicellular Agent-based Model)
18/08/23
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New Prostate Cancer Data Has Been Reported by a Researcher at Eindhoven University of Technology (Radiogenomics Analysis Linking Multiparametric MRI and Transcriptomics in Prostate Cancer)
Mischi, M., Wijkstra, H., Turco, S., Eduati, F. & Zwart, W. T.
27/06/23
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Pers / media: Vakinhoudelijk commentaar
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Combi-seq: A leap forward for personalized cancer therapy
29/09/22
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Eindhoven University of Technology: Stein Stoter Wins Postdoc Paper Pitch Competition
Baaijens, F. P. T., Heck, M. J. R., Fitzgerald, B., Eduati, F., Costa Figueiredo, M., Jorba Masdéu, I., Stoter, K. F. S. & Hogervorst, T.
19/05/22
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Stein Stoter wins postdoc paper pitch competition
Baaijens, F. P. T., Heck, M. J. R., Fitzgerald, B., Eduati, F., Costa Figueiredo, M., Jorba Masdéu, I., Stoter, K. F. S. & Hogervorst, T.
19/05/22
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Pers / media: Vakinhoudelijk commentaar