• 271 Citaties
20102020

Research output per year

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Persoonlijk profiel

Research profile

Federica Eduati is an assistant professor at the department Biomedical Engineering (research group Computational Biology), working on systems biology for oncology. She investigates why patients differentially respond to cancer therapy, and how personalized therapy based on biomarkers can be developed. In particular, she approaches the complex problem of precision medicine by applying dynamic mathematical modeling approaches and machine learning techniques to investigate signaling pathways, their deregulation in cancer, and the specific effect of targeted therapy. Since precision medicine would largely benefit from the possibility to perform phenotypic drug screening directly on live patient tumor cells, she has also been collaborating on the development of a microfluidics platform for this purpose. She is now expanding her research to study the interaction between tumor and immune cells, using a systems biology approach to tackle the multiple open questions of immuno-oncology.

Quote

I want to contribute to the improvement of cancer therapy, using systems approaches to gain important insights into the complexity of tumors.

Academic background

Federica Eduati received a BSc in Biomedical Engineering (2006) and a MSc in Bioengineering (2008) from the University of Padova, Italy (both cum laude). During her PhD research she worked in the field of systems biology using different computational modeling approaches in order to gain new insights into biological systems. Following her graduation in 2013, she became a postdoc (EMBL EIPOD, co-funded Marie Curie fellowship) at the European Molecular Biology Laboratory (EMBL), shared between the Systems Biomedicine group of Julio Saez-Rodriguez at EMBL-EBI (Cambridge, UK) and the microfluidics group of Christoph Merten at EMBL-HD (Heidelberg, Germany). Since 2018 she is assistant professor in the Computational Biology group at Eindhoven University of Technology (TU/e, The Netherlands), working on systems biology for (immuno-)oncology. In 2013, Federica was co-organizer of the NIEHS-NCATS-UNC DREAM Toxicogenetics Challenge (http://dreamchallenges.org/).

Vingerafdruk Verdiep u in de onderzoeksgebieden waarop Federica Eduati actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

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Onderzoeksoutput

  • 271 Citaties
  • 15 Tijdschriftartikel
  • 1 Conferentiebijdrage
  • 1 Artikel recenseren

Patient-specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies

Eduati, F., Jaaks, P., Wappler, J., Cramer, T., Merten, C. A., Garnett, M. J. & Saez-Rodriguez, J., feb 2020, In : Molecular Systems Biology. 16, 2, 13 blz., e8664.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
  • 1 Citaat (Scopus)
    32 Downloads (Pure)

    A microfluidics platform for combinatorial drug screening on cancer biopsies

    Eduati, F., Utharala, R., Madhavan, D., Neumann, U. P., Longerich, T., Cramer, T., Saez-Rodriguez, J. & Merten, C. A., 22 jun 2018, In : Nature Communications. 9, 1, 13 blz., 2434.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
    Bestand
  • 32 Citaten (Scopus)
    136 Downloads (Pure)

    Multi-omics profiling of the tumor microenvironment: Paving the way to precision immuno-oncology

    Finotello, F. & Eduati, F., 5 okt 2018, In : Frontiers in Oncology. 8, OCT, 9 blz., 430.

    Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

    Open Access
    Bestand
  • 13 Citaten (Scopus)
    63 Downloads (Pure)

    Drug resistance mechanisms in colorectal cancer dissected with cell type-specific dynamic logic models

    Eduati, F., Doldàn-Martelli, V., Klinger, B., Cokelaer, T., Sieber, A., Kogera, F., Dorel, M., Garnett, M. J., Blüthgen, N. & Saez-Rodriguez, J., 15 jun 2017, In : Cancer Research. 77, 12, blz. 3364-3375 12 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
  • 38 Citaten (Scopus)

    Logic modeling in quantitative systems pharmacology

    Traynard, P., Tobalina, L., Eduati, F., Calzone, L. & Saez-Rodriguez, J., 1 aug 2017, In : CPT: Pharmacometrics & Systems Pharmacology. 6, 8, blz. 499-511 13 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
    Bestand
  • 8 Citaten (Scopus)
    36 Downloads (Pure)

    Cursussen

    OGO Oncologie

    1/09/13 → …

    Cursus

    Project Computational biology

    1/09/1431/08/20

    Cursus

    Knipsels

    Germany : Miniature testing of drug pairs on tumour biopsies

    Federica Eduati

    26/06/18

    1 item van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    Miniature Testing of Drug Pairs on Tumour Biopsies

    F. Eduati

    25/06/18

    1 item van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    Miniature testing of drug pairs on tumour biopsies

    Federica Eduati

    22/06/1825/06/18

    3 items van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    New Device Enables Test for Cancer Drug Combinations on Tumor Biopsies

    Federica Eduati

    25/06/18

    1 item van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    Miniature Testing of Drug Pairs on Tumor Biopsies

    Federica Eduati

    25/06/18

    2 items van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    Scriptie

    Primary tumor origin classification of lung nodules in spectral CT using transfer learning

    Auteur: Hesse, L., 20 jun 2019

    Begeleider: Pluim, J. (Afstudeerdocent 1), de Jong, P. A. (Externe persoon) (Externe coach), Cheplygina, V. (Afstudeerdocent 2) & Eduati, F. (Afstudeerdocent 2)

    Scriptie/masterproef: Master

    Re-referencing methods for high-density electrocorticographic signals: evaluating alternatives of common average re-referencing

    Auteur: Pilmeyer, J., 29 nov 2018

    Begeleider: Pluim, J. (Afstudeerdocent 1), Cheplygina, V. (Afstudeerdocent 2), Eduati, F. (Afstudeerdocent 2), Freudenburg, Z. (Externe persoon) (Externe coach) & Branco, M. (Externe persoon) (Externe coach)

    Scriptie/masterproef: Master

    Segmentation and classification of skin cancer in histopathological whole slide images

    Auteur: van Zon, M., 28 nov 2019

    Begeleider: Pluim, J. P. (Afstudeerdocent 1), Veta, M. (Afstudeerdocent 2), Eduati, F. (Afstudeerdocent 2), van Diest, P. J. (Externe persoon) (Externe coach) & Stathonikos, N. (Externe persoon) (Externe coach)

    Scriptie/masterproef: Master

    Tackling B1+ inhomogeneity problems at high field MRI to be able to predict neoadjuvant chemotherapy response in breast cancer patients

    Auteur: Elschot, E., 30 jan 2020

    Begeleider: Raaijmakers, A. (Afstudeerdocent 1), Breeuwer, M. (Afstudeerdocent 2), Eduati, F. (Afstudeerdocent 2), Wijnen, J. P. (Externe coach) & van den Wildenberg, L. (Externe coach)

    Scriptie/masterproef: Master

    Bestand