Emira Visser started as a doctoral candidate at the Technical University of Eindhoven in April 2019 under the supervision of prof.dr.ir. Luc Brunsveld and dr. Christian Ottmann. Her project is based on a collaboration between the Laboratory of Chemical Biology at the TU/e and the lab of Oncogenomics at the Netherlands Cancer Insitute in the group of prof.dr. Wilbert Zwart. In Eindhoven she focuses on the identification of small molecule stabilizers that act as 'molecular glues' enhancing interaction between proteins. These stabilizing molecules will be subsequently tested in physiologically relevant cell lines in the lab of Wilbert Zwart, thereby gaining more insight in the cellular consequences of PPI stabilization. This approach aims to provide alternative treatment opportunities to tackle the therapeutic resistance observed in breast cancer.
Emira Visser received her bachelor degree in Biomedical Engineering at the Technical University of Eindhoven in 2016, after which she continued with her Master of Science in the same field. During her master she graduated in the field of Chemical Biology in the group of prof. dr. ir. Luc Brunsveld and dr. Christian Ottmann. In this research, the stabilization of two proteins, important for metabolic disease, was analyzed and small molecule stabilizers were discovered using molecular docking approaches. Hereafter she joined the group of dr. Seth Masters at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, Australia. Here she investigated the role of bile acid derivatives in autoinflammatory disease. In 2019 she started her PhD at the TU/e in collaboration with The Netherlands Cancer Insititute (NKI-AVL) in Amsterdam under supervision of prof.dr.ir Luc Brunsveld and prof.dr. Wilbert Zwart.
Discovery of new stabilizers for a unique 14-3-3 protein interaction with ChREBP by molecular dockingAuteur: Visser, E., 28 mrt 2019