• 240 Citaties
20162020

Onderzoeksresultaten per jaar

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Persoonlijk profiel

Research profile

Eline Sijbesma is a PhD student in the Chemical Biology research group of professor Luc Brunsveld. Her current research focusses on the exploration of fragment-based drug discovery to identify small molecule stabilizers, that act as 'molecular glues' enhancing interactions between proteins. This approach is inspired by nature - which makes extensive use of the stabilization of protein complexes - and aims to provide new modalities to expand the druggable proteome, address therapeutic resistance and tackle challenging diseases.

Quote

Interactions between proteins are at the core of all biological processes yet inherently challenging drug targets. This inspires us to employ unexplored approaches at the forefronts of drug discovery.

Academic background

Eline Sijbesma first joined the Chemical Biology group as an undergraduate student. During her MSc graduation project she worked on elucidating the binding mode of natural compound Estrogen Receptor modulators. Part of this research was performed in the group of dr. Wilbert Zwart at the Netherlands Cancer Institute (NKI-AVL). She then joined the Small Molecule Discovery Center (SMDC) in the group of prof. Michelle Arkin, PhD at the University of California in San Francisco (UCSF) where she initiated a fragment-based drug discovery project that explores protein-protein interactions as novel drug targets. For this research internship she was awarded a travel grant from the Nora Baart Foundation (NVBMB) and a Scholarship by the Dr Hendrik Muller’s Fund. Eline obtained her Master of Science degree cum laude in 2015 and started her PhD under supervision of prof. dr. ir. Luc Brunsveld and dr. Christian Ottmann.

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  • 17 Soortgelijke profielen

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Onderzoeksoutput

  • 240 Citaties
  • 10 Tijdschriftartikel
  • 1 Artikel recenseren
  • 1 Dissertatie 1 (Onderzoek TU/e / Promotie TU/e)

A supramolecular stabilizer of the 14-3-3ζ/ERα protein-protein interaction with a synergistic mode of action

Gigante, A., Sijbesma, E., Sánchez-Murcia, P. A., Hu, X., Bier, D., Bäcker, S., Knauer, S., Gago, F., Ottmann, C. & Schmuck, C., 11 feb 2020, In : Angewandte Chemie - International Edition. 59, 13, blz. 5284-5287 4 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
  • 1 Citaat (Scopus)
    24 Downloads (Pure)

    Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions

    Sijbesma, E., Visser, E., Plitzko, K., Thiel, P., Milroy, L. G., Kaiser, M., Brunsveld, L. & Ottmann, C., 7 aug 2020, In : Nature Communications. 11, 1, 9 blz., 3954.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
  • Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteins

    Maity, D., Gigante, A., Sánchez-Murcia, P. A., Sijbesma, E., Li, M., Bier, D., Mosel, S., Knauer, S., Ottmann, C. & Schmuck, C., 2 apr 2019, In : Organic & Biomolecular Chemistry. 17, 17, blz. 4359-4363 5 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • 3 Citaten (Scopus)
    2 Downloads (Pure)

    Modulating protein–protein interaction networks in protein homeostasis

    Zhong, M., Lee, G. M., Sijbesma, E., Ottmann, C. & Arkin, M. R., 1 jun 2019, In : Current Opinion in Chemical Biology. 50, blz. 55-65 11 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

  • 9 Citaten (Scopus)
    3 Downloads (Pure)

    Site-directed fragment-based screening for the discovery of protein-protein interaction stabilizers

    Sijbesma, E., Hallenbeck, K. K., Leysen, S., de Vink, P. J., Skóra, L., Jahnke, W., Brunsveld, L., Arkin, M. R. & Ottmann, C., 27 feb 2019, In : Journal of the American Chemical Society. 141, 8, blz. 3524–3531 8 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • 20 Citaten (Scopus)
    10 Downloads (Pure)

    Knipsels

    Eindhoven University of Technology: Search for Molecular Glue in Targeted Disease Control

    Eline Sijbesma

    15/08/20

    1 item van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    Search for molecular glue in targeted disease control

    Eline Sijbesma

    14/08/20

    1 item van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    Scriptie

    Elucidating the dual mechanism of natural product-based Estrogen Receptor modulation

    Auteur: Sijbesma, E., 31 okt 2015

    Begeleider: Zwart, W. (Externe persoon) (Afstudeerdocent 1), Leysen, S. (Afstudeerdocent 2), Scheepstra, M. (Afstudeerdocent 2) & Brunsveld, L. (Afstudeerdocent 2)

    Scriptie/Masterproef: Master