• 2966 Citaties

Onderzoeksresultaten per jaar

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Persoonlijk profiel


"As a scientist I feel that I have to give something back to society. I am doing that by helping to solve hard-to-crack biomedical problems such as drugging protein-protein interactions."

Research profile

Christian Ottmann is Associate Professor of Molecular Cell and Structural Biology at the department of Biomedical Engineering (research group Chemical Biology). He works on small-molecule modulation of Protein-Protein Interactions (PPIs) with a special focus on stabilization of 14-3-3 adapter protein PPIs. He is involved in several early drug discovery projects with the pharmaceutical industry, targeting disease as diverse as cancer, Alzheimer’s disease, inflammation and cystic fibrosis. In this context he also is coordinator of the FP7 Industry-Academia Partnership and Pathways (IAPP) 14-3-3STABS and the Horizon2020 European Training Network (ETN) TASPPI. 

Academic background

Christian Ottmann studied Biology (Dipl.) at the Ruhr-University in Bochum (Germany). From 1999-2003, he did his PhD research at the Eberhard-Karls-University of Tübingen under supervision of Prof. Claudia Oecking and graduated summa cum laude. From 2003-2004, he was a Postdoctoral Research Assistant with Prof. Oecking. Beginning of 2005, he founded the biotech company AmbAgon Technology in Dortmund, Germany. In 2006, he became a group leader at the Chemical Genomics Centre (CGC) of the Max Planck Society (Dortmund, Germany). In 2012, Christian Ottmann was appointed Associate Professor of Molecular and Structural Cell Biology at the department of Biomedical Engineering of Eindhoven University of Technology (TU/e). In that same year he was recipient of the Innovation Award in Medicinal/Pharmaceutical Chemistry of the Gesellschaft Deutscher Chemiker and the Deutsche Pharmazeutische Gesellschaft. In 2013, Christian Ottmann received the Young Chemical Biologist Award of the International Chemical Biology Society (ICBS). In 2014 he was appointed professor at the Institute for Organic Chemistry of the University of Duisburg-Essen (Germany).

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Adoption of a turn conformation drives the binding affinity of p53 C-terminal domain peptides to 14-3-3σ

Kuusk, A., Neves, J. F., Bravo-Rodriguez, K., Gunnarsson, A., Ruiz-Blanco, Y. B., Ehrmann, M., Chen, H., Landrieu, I., Sanchez-Garcia, E., Boyd, H., Ottmann, C. & Doveston, R. G., 17 jan 2020, In : ACS Chemical Biology. 15, 1, blz. 262-271 10 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
  • 15 Downloads (Pure)

    A supramolecular stabilizer of the 14-3-3ζ/ERα protein-protein interaction with a synergistic mode of action

    Gigante, A., Sijbesma, E., Sánchez-Murcia, P. A., Hu, X., Bier, D., Bäcker, S., Knauer, S., Gago, F., Ottmann, C. & Schmuck, C., 11 feb 2020, In : Angewandte Chemie - International Edition. 59, 13, blz. 5284-5287 4 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
  • 1 Citaat (Scopus)
    15 Downloads (Pure)

    Conjugated protein domains as engineered scaffold proteins

    Lemmens, L., Ottmann, C. & Brunsveld, L., 17 jun 2020, In : Bioconjugate Chemistry. 31, 6, blz. 1596-1603 8 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • Design of Drug-Like Protein–Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization

    Bosica, F., Andrei, S. A., Neves, J. F., Brandt, P., Gunnarsson, A., Landrieu, I., Ottmann, C. & O'Mahony, G., 2 jun 2020, In : Chemistry - A European Journal. 26, 31, blz. 7131-7139 9 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • Discovery of small-molecule stabilizers of 14-3-3 protein-protein interactions via dynamic combinatorial chemistry

    Hartman, A. M., Elgaher, W. A. M., Hertrich, N., Andrei, S. A., Ottmann, C. & Hirsch, A. K. H., 14 mei 2020, In : ACS Medicinal Chemistry Letters. 11, 5, blz. 1041-1046 6 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • Cursussen

    Chemische biologie




    1/09/13 → …


    Project Moleculaire biologie

    1/09/15 → …



    Cell directed nanoparticle drug delivery for tissue engineering

    Auteur: Vogel, M., 30 sep 2015

    Begeleider: Bouten, C. (Afstudeerdocent 1), Sahlgren, C. (Afstudeerdocent 2), Ottmann, C. (Afstudeerdocent 2) & Kurniawan, N. (Externe coach)

    Scriptie/masterproef: Master

    Characterization of the interaction of 14-3-3 proteins and estrogen receptor alpha as a potential drug target

    Auteur: den Hamer, A., 30 nov 2013

    Begeleider: de Vries - van Leeuwen, I. (Externe coach), Tharun, I. (Afstudeerdocent 1), Ottmann, C. (Afstudeerdocent 2) & Brunsveld, L. (Afstudeerdocent 2)

    Scriptie/masterproef: Master

    Creating a non-linear response in dCas9-based gene repression: tuning the sgRNA concentration with the use of enzymatic coupled degradation

    Auteur: Uittenbogaard, P., 20 mei 2019

    Begeleider: Hilbers, P. (Afstudeerdocent 1), de Greef, T. (Afstudeerdocent 2), Ottmann, C. (Afstudeerdocent 2) & Dubuc, E. (Afstudeerdocent 2)

    Scriptie/masterproef: Master

    Discovery of new stabilizers for a unique 14-3-3 protein interaction with ChREBP by molecular docking

    Auteur: Visser, E., 28 mrt 2019

    Begeleider: Ottmann, C. (Afstudeerdocent 1), Sijbesma, E. (Afstudeerdocent 2) & Brunsveld, L. (Afstudeerdocent 2)

    Scriptie/masterproef: Master

    Dual-isotope SPECT comparison of 111In/177Lu radiolabelled tumor-targeting nanobodies

    Auteur: Rompen, R., 31 aug 2015

    Begeleider: Nicolaij, K. (Afstudeerdocent 1), Grüll, H. (Afstudeerdocent 2), Rossin, R. (Afstudeerdocent 2), Oliveira, S. (Externe persoon) (Externe coach), van Bergen en Henegouwen, P. M. (Externe persoon) (Externe coach) & Ottmann, C. (Afstudeerdocent 2)

    Scriptie/masterproef: Master