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Persoonlijk profiel

Quote

“The intriguing capacity of living cells to shape and adapt their own environment teaches us how to engineer new tissues for the heart.”

Research profile

Carlijn Bouten is professor of Cell-Matrix Interactions in Cardiovascular Regeneration at the department of Biomedical Engineering (research group Soft Tissue Engineering & Mechanobiology). Her research group investigates the interplay between living cells and the mechanobiological cues originating from the extracellular matrix under conditions of tissue growth, adaptation, and regeneration and degeneration. The group uses ‘living’ model systems at different length scales (cell, cell-matrix, engineered tissue, native tissue) to quantify these aspects, preferably in real-time.

The obtained knowledge is applied in engineering approaches to regenerate living tissues, in particular for the human heart. A prominent example is the development of a synthetic, biodegradable heart valve prosthesis that seduces the body to create a new, living heart valve at the site of implantation. Bouten performs her multidisciplinary research in close collaboration with material scientists, life scientists, clinicians, and medtech spin-offs. She leads several national and international public-private-patient research consortia in the field of Regenerative Medicine and Tissue Engineering.

Academic background

Carlijn Bouten was trained in functional anatomy and biomechanics as well as muscle physiology at the department of Human Movement Sciences of Vrije Universiteit Amsterdam, where she received her MSc degree in 1991. In 1995, she obtained her PhD degree from Eindhoven University of Technology (TU/e, the Netherlands). She performed postdoctoral research at the Université Laval (Quebec), University of London, and at TU/e. In 1998, she was appointed assistant professor in Cellular Biomechanics in the department of Mechanical Engineering at TU/e, and in 2002 she became associate professor of Tissue Engineering in the department of Biomedical Engineering at the same university. In 2010, Carlijn Bouten was appointed full professor of Cell-Matrix Interaction in Cardiovascular Regeneration at TU/e. She is a recipient of the Aspasia Career Development award of the Dutch Science Foundation NWO (2002), which awarded her a VICI grant for her research on heart valve tissue engineering in 2003. From 2005-2010 Bouten was member of The Young Academy of the Royal Netherlands Academy of Arts and Sciences (KNAW).Since 2017, she leads the national gravitation program Materials-Driven Regeneration. In that same year she was elected member of the KNAW.

Vingerafdruk Duik in de onderzoeksthema's waar Carlijn V.C. Bouten actief is. Deze onderwerplabels komen voort uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

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Tissue Engineering Medicijnen en Levenswetenschappen
Heart Valves Medicijnen en Levenswetenschappen
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Tissue engineering Engineering en materiaalwetenschappen
Scaffolds Engineering en materiaalwetenschappen
Scaffolds (biology) Engineering en materiaalwetenschappen
Blood Vessels Medicijnen en Levenswetenschappen

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Onderzoeksoutput 1991 2020

1 Citaat (Scopus)
3 Downloads (Pure)

Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements

Fioretta, E., Lintas, V., Mallone, A., Motta, S. E., von Boehmer, L., Dijkman, P. E., Cesarovic, N., Caliskan, E., Rodriguez Cetina Biefer, H., Lipiski, M., Sauer, M., Putti, M., Janssen, H. M., Söntjens, S. H. M., Smits, A. I. P. M., Bouten, C. V. C., Emmert, M. Y. & Hoerstrup, S. P., 1 jan 2020, In : JACC: Basic to Translational Science. 5, 1, blz. 15-31 17 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Pulmonary Valve
Heart Valves
Bone Marrow Cells
polycarbonate
Sheep

Early cost-utility analysis of tissue-engineered heart valves compared to bioprostheses in the aortic position in elderly patients

Huygens, S. A., Ramos, I. C., Bouten, C. V. C., Kluin, J., Chiu, S. T., Grunkemeier, G. L., Takkenberg, J. J. M. & Rutten-van Mölken, M. P. M. H., 25 jan 2020, In : European Journal of Health Economics.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bioprosthesis
Heart Valves
Cost-Benefit Analysis
Quality-Adjusted Life Years
Costs and Cost Analysis
1 Downloads (Pure)

Fibrotic aortic valve disease after radiotherapy: an immunohistochemical study in breast cancer and lymphoma patients

van Rijswijk, J. W., Farag, E. S., Bouten, C. V. C., de Boer, O. J., van der Wal, A., de Mol, B. A. J. M. & Kluin, J., 1 mrt 2020, In : Cardiovascular Pathology. 45, 7 blz., 107176.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Aortic Diseases
Aortic Valve
Lymphoma
Radiotherapy
Breast Neoplasms
8 Downloads (Pure)
Open Access
Bestand
Macrophages
Hemodynamics
Biocompatible Materials
Tissue engineering
Biomaterials
3 Downloads (Pure)

Layer-specific cell differentiation in bi-layered vascular grafts under flow perfusion

Pennings, I., van Haaften, E. E., Juengst, T., Bulsink, J. A., Rosenberg, A. J. W. P., Groll, J., Bouten, C. V. C., Kurniawan, N. A., Smits, A. I. P. M. & Gawlitta, D., jan 2020, In : Biofabrication. 12, 1, 13 blz., 015009.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Grafts
Blood Vessels
Cell Differentiation
Perfusion
Transplants

Prijzen

Materials-driven regeneration

C.V.C. Bouten (Ontvanger), 2016

Prijs: NWOZwaartekrachtWetenschappelijk

Netherlands
selection procedure
Ministry of Education
funding
organization

Activiteiten 1993 1993

  • 4 Aangemelde presentatie

16th Annual Int. Conf. IEEE Eng. in Medicine and Biology, San Diego, USA

Carlijn V.C. Bouten (Spreker)
29 okt 1993

Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk

UT, BMTI

Carlijn V.C. Bouten (Spreker)
5 okt 1993

Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk

RL Maastricht

Carlijn V.C. Bouten (Spreker)
24 sep 1993

Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk

2e Plenaire wetenschappelijke dag RL/TUE, Eindhoven

Carlijn V.C. Bouten (Spreker)
17 sep 1993

Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk

Cursussen

Hart en bloed

1/09/15 → …

Cursus

Regeneratie

1/09/13 → …

Cursus

Pers/media

TU/e Shortlisted for 35 Million Euro Award for Research on Cardiovascular Diseases

Frans N. van de Vosse & Carlijn V.C. Bouten

25/01/2027/01/20

2 items van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

-Eindhoven University of Technology: Carlijn Bouten appointed as board member of ZonMw

Carlijn V.C. Bouten

10/01/20

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Carlijn Bouten appointed as board member ZonMw

Carlijn V.C. Bouten

6/01/20

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Eindhoven University of Technology: Carlijn Bouten Appointed as Board Member of ZonMw

Carlijn V.C. Bouten

6/01/20

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Young Academy welcomes Liesbeth Janssen

Carlijn V.C. Bouten & Tom F.A. de Greef

10/12/19

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Scriptie

A 2-D finite element model of a muscle cell in agarose gel-matrix

Auteur: Tran, N. H., 29 feb 2000

Begeleider: Baaijens, F. (Afstudeerdocent 1), Oomens, C. (Afstudeerdocent 2), Bouten, C. (Afstudeerdocent 2) & Breuls, R. (Afstudeerdocent 2)

Scriptie/masterproef: Master

A 3-D finite element model of the tibialis anterior muscle of a rat: a contribution to pressure sores research

Auteur: Breuls, R., 31 mrt 1998

Begeleider: Janssen, J. (Afstudeerdocent 1), Oomens, C. (Afstudeerdocent 2), Bosboom, E. (Afstudeerdocent 2) & Bouten, C. (Afstudeerdocent 2)

Scriptie/masterproef: Master

A brain chip to investigate neurite outgrowth by trapping cell-laden hydrogel beads in microsieves

Auteur: Labeur, T., 29 aug 2019

Begeleider: Bouten, C. (Afstudeerdocent 1), Luttge, R. (Afstudeerdocent 2), Kurniawan, N. (Afstudeerdocent 2) & Bastiaens, A. (Afstudeerdocent 2)

Scriptie/masterproef: Master

A finite element model to study the viability of muscle cells under compression

Auteur: Hendriks, F., 30 jun 1999

Begeleider: Baaijens, F. (Afstudeerdocent 1), Oomens, C. (Afstudeerdocent 2), Bouten, C. (Afstudeerdocent 2) & Breuls, R. (Afstudeerdocent 2)

Scriptie/masterproef: Master

A multilevel finite element method for studying muscle cell damage

Auteur: Sengers, B., 30 nov 2000

Begeleider: Oomens, C. (Afstudeerdocent 1), Baaijens, F. (Afstudeerdocent 2), Bouten, C. (Afstudeerdocent 2) & Breuls, R. (Afstudeerdocent 2)

Scriptie/masterproef: Master