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Persoonlijk profiel

Quote

“The intriguing capacity of living cells to shape and adapt their own environment teaches us how to engineer new tissues for the heart.”

Research profile

Carlijn Bouten is professor of Cell-Matrix Interactions in Cardiovascular Regeneration at the department of Biomedical Engineering (research group Soft Tissue Engineering & Mechanobiology). Her research group investigates the interplay between living cells and the mechanobiological cues originating from the extracellular matrix under conditions of tissue growth, adaptation, and regeneration and degeneration. The group uses ‘living’ model systems at different length scales (cell, cell-matrix, engineered tissue, native tissue) to quantify these aspects, preferably in real-time.

The obtained knowledge is applied in engineering approaches to regenerate living tissues, in particular for the human heart. A prominent example is the development of a synthetic, biodegradable heart valve prosthesis that seduces the body to create a new, living heart valve at the site of implantation. Bouten performs her multidisciplinary research in close collaboration with material scientists, life scientists, clinicians, and medtech spin-offs. She leads several national and international public-private-patient research consortia in the field of Regenerative Medicine and Tissue Engineering.

Academic background

Carlijn Bouten was trained in functional anatomy and biomechanics as well as muscle physiology at the department of Human Movement Sciences of Vrije Universiteit Amsterdam, where she received her MSc degree in 1991. In 1995, she obtained her PhD degree from Eindhoven University of Technology (TU/e, the Netherlands). She performed postdoctoral research at the Université Laval (Quebec), University of London, and at TU/e. In 1998, she was appointed assistant professor in Cellular Biomechanics in the department of Mechanical Engineering at TU/e, and in 2002 she became associate professor of Tissue Engineering in the department of Biomedical Engineering at the same university. In 2010, Carlijn Bouten was appointed full professor of Cell-Matrix Interaction in Cardiovascular Regeneration at TU/e. She is a recipient of the Aspasia Career Development award of the Dutch Science Foundation NWO (2002), which awarded her a VICI grant for her research on heart valve tissue engineering in 2003. From 2005-2010 Bouten was member of The Young Academy of the Royal Netherlands Academy of Arts and Sciences (KNAW).Since 2017, she leads the national gravitation program Materials-Driven Regeneration. In that same year she was elected member of the KNAW.

Vingerafdruk Verdiep u in de onderzoeksgebieden waarop Carlijn V.C. Bouten actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

  • 37 Soortgelijke profielen

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Onderzoeksoutput

Cellular geometry sensing at different length scales and its implications for scaffold design

Werner, M., Kurniawan, N. A. & Bouten, C. V. C., 1 feb 2020, In : Materials. 13, 4, 18 blz., 963.

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

Open Access
Bestand
  • 1 Citaat (Scopus)
    21 Downloads (Pure)

    Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements

    Fioretta, E., Lintas, V., Mallone, A., Motta, S. E., von Boehmer, L., Dijkman, P. E., Cesarovic, N., Caliskan, E., Rodriguez Cetina Biefer, H., Lipiski, M., Sauer, M., Putti, M., Janssen, H. M., Söntjens, S. H. M., Smits, A. I. P. M., Bouten, C. V. C., Emmert, M. Y. & Hoerstrup, S. P., 1 jan 2020, In : JACC: Basic to Translational Science. 5, 1, blz. 15-31 17 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
    Bestand
  • 2 Citaten (Scopus)
    9 Downloads (Pure)

    Early cost-utility analysis of tissue-engineered heart valves compared to bioprostheses in the aortic position in elderly patients

    Huygens, S. A., Ramos, I. C., Bouten, C. V. C., Kluin, J., Chiu, S. T., Grunkemeier, G. L., Takkenberg, J. J. M. & Rutten-van Mölken, M. P. M. H., 1 jun 2020, In : European Journal of Health Economics. 21, 4, blz. 557-572 16 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
  • Failure of decellularized porcine small intestinal submucosa as a heart valved conduit

    van Rijswijk, J. W., Talacua, H., Mulder, K., van Hout, G. P. J., Bouten, C. V. C., Gründeman, P. F. & Kluin, J., 10 jan 2020, In : Journal of Thoracic and Cardiovascular Surgery.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • 1 Citaat (Scopus)

    Fibrotic aortic valve disease after radiotherapy: an immunohistochemical study in breast cancer and lymphoma patients

    van Rijswijk, J. W., Farag, E. S., Bouten, C. V. C., de Boer, O. J., van der Wal, A., de Mol, B. A. J. M. & Kluin, J., 1 mrt 2020, In : Cardiovascular Pathology. 45, 7 blz., 107176.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • 1 Downloads (Pure)

    Prijzen

    Materials-driven regeneration

    C.V.C. Bouten (Ontvanger), 2016

    Prijs: NWOZwaartekrachtWetenschappelijk

  • Activiteiten

    • 4 Aangemelde presentatie

    16th Annual Int. Conf. IEEE Eng. in Medicine and Biology, San Diego, USA

    Carlijn V.C. Bouten (Spreker)
    29 okt 1993

    Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk

    UT, BMTI

    Carlijn V.C. Bouten (Spreker)
    5 okt 1993

    Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk

    RL Maastricht

    Carlijn V.C. Bouten (Spreker)
    24 sep 1993

    Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk

    2e Plenaire wetenschappelijke dag RL/TUE, Eindhoven

    Carlijn V.C. Bouten (Spreker)
    17 sep 1993

    Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk

    Cursussen

    Hart en bloed

    1/09/15 → …

    Cursus

    Regeneratie

    1/09/13 → …

    Cursus

    Knipsels

    TU/e Shortlisted for 35 Million Euro Award for Research on Cardiovascular Diseases

    Frans N. van de Vosse & Carlijn V.C. Bouten

    25/01/2027/01/20

    2 items van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    -Eindhoven University of Technology: Carlijn Bouten appointed as board member of ZonMw

    Carlijn V.C. Bouten

    10/01/20

    1 item van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    Carlijn Bouten appointed as board member ZonMw

    Carlijn V.C. Bouten

    6/01/20

    1 item van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    Eindhoven University of Technology: Carlijn Bouten Appointed as Board Member of ZonMw

    Carlijn V.C. Bouten

    6/01/20

    1 item van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    Young Academy welcomes Liesbeth Janssen

    Carlijn V.C. Bouten & Tom F.A. de Greef

    10/12/19

    1 item van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    Scriptie

    A 2-D finite element model of a muscle cell in agarose gel-matrix

    Auteur: Tran, N. H., 29 feb 2000

    Begeleider: Baaijens, F. (Afstudeerdocent 1), Oomens, C. (Afstudeerdocent 2), Bouten, C. (Afstudeerdocent 2) & Breuls, R. (Afstudeerdocent 2)

    Scriptie/masterproef: Master

    A 3-D finite element model of the tibialis anterior muscle of a rat: a contribution to pressure sores research

    Auteur: Breuls, R., 31 mrt 1998

    Begeleider: Janssen, J. (Afstudeerdocent 1), Oomens, C. (Afstudeerdocent 2), Bosboom, E. (Afstudeerdocent 2) & Bouten, C. (Afstudeerdocent 2)

    Scriptie/masterproef: Master

    A brain chip to investigate neurite outgrowth by trapping cell-laden hydrogel beads in microsieves

    Auteur: Labeur, T., 29 aug 2019

    Begeleider: Bouten, C. (Afstudeerdocent 1), Luttge, R. (Afstudeerdocent 2), Kurniawan, N. (Afstudeerdocent 2) & Bastiaens, A. (Afstudeerdocent 2)

    Scriptie/masterproef: Master

    A finite element model to study the viability of muscle cells under compression

    Auteur: Hendriks, F., 30 jun 1999

    Begeleider: Baaijens, F. (Afstudeerdocent 1), Oomens, C. (Afstudeerdocent 2), Bouten, C. (Afstudeerdocent 2) & Breuls, R. (Afstudeerdocent 2)

    Scriptie/masterproef: Master

    A multilevel finite element method for studying muscle cell damage

    Auteur: Sengers, B., 30 nov 2000

    Begeleider: Oomens, C. (Afstudeerdocent 1), Baaijens, F. (Afstudeerdocent 2), Bouten, C. (Afstudeerdocent 2) & Breuls, R. (Afstudeerdocent 2)

    Scriptie/masterproef: Master