• Het Kranenveld, Helix, STO 4.45

    Eindhoven

    Nederland

Organisatieprofiel

Introductie / missie

Inspired by enzymes we develop synthetic analogues with high selectivity and activity, that function in concert with natural biocatalysts. 

Highlighted phrase

Towards synthetic enzymes

Over de organisatie

At the Supramolecular Chemistry and Catalysis group, we work towards the integration of biological and chemical processes to generate non-natural conversions in complex media. We explore the exciting opportunities that arise from the integration of polymer chemistry, supramolecular chemistry and stereochemistry with the novel field of bio-orthogonal chemistry, that studies chemical reactions to augment biochemical processes. Using this integrated approach, we focus on the design and synthesis of (supramolecular) copolymers that form nanometer-sized structures with the aim to achieve efficient and selective catalysis in water and in complex cellular media. Developing such complex molecular systems based on non-covalent, reversible interactions, and understanding the mechanisms underlying their formation, will provide a solid foundation to progress towards in vivo applications.

Our ultimate goal is to develop synthetic enzyme analogues that can perform bio-orthogonal catalysis in concert with their natural counterparts, and that display similar activity and selectivity. To achieve this, we design and synthesise amphiphilic systems - either using covalent polymers with pendant sticky groups that fold into compartmentalised structures in aqueous media, or using supramolecular copolymers with pendant functional groups.

Our research develops along two lines: Development of single-chain polymeric nanoparticles for catalysis in water and complex media, and Understanding supramolecular copolymerisations.

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    Onderzoeksoutput

    • 20 Tijdschriftartikel
    • 1 Inaugurale rede
    • 1 Artikel recenseren
    • 1 Dissertatie 1 (Onderzoek TU/e / Promotie TU/e)

    Amphiphilic Polymeric Nanoparticles for Photoredox Catalysis in Water

    Eisenreich, F., Meijer, E. W. & Palmans, A. R., 19 mei 2020, In : Chemistry (Weinheim an der Bergstrasse, Germany). 8 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
  • Anchoring supramolecular polymers to human red blood cells by combining dynamic covalent and non-covalent chemistries

    Meijer, B., Morgese, G., de Waal, B. F. M., Varela-Aramburu, S., Palmans, A. R. A. & Albertazzi, L., 25 jun 2020, In : Angewandte Chemie - International Edition.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
  • Architecture-dependent interplay between self-assembly and crystallization in discrete block co-oligomers

    Petkau-Milroy, K., Ianiro, A., Ahn, M. M. L., Magana, J. R., Vleugels, M. E. J., Lamers, B. A. G., Tuinier, R., Voets, I. K., Palmans, A. R. A. & Meijer, E. W., 21 jan 2020, In : ACS Macro Letters. 9, 1, blz. 38-42 5 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
    Bestand
  • 22 Downloads (Pure)

    Scripties/Masterproeven

    Perfluorinated polymeric nanoparticles for catalysis

    Auteur: Aarts, J., 30 jan 2020

    Begeleider: Sklorz, J. A. (Afstudeerdocent 1), Palmans, A. R. (Afstudeerdocent 2) & Meijer, E. (. (Afstudeerdocent 1)

    Scriptie/Masterproef: Master

    Solar water splitting using chiral squaraine dyes: an exploration of the chiral-induced spin selectivity effect

    Auteur: Robben, J., 29 apr 2020

    Begeleider: Rösch, A. (Afstudeerdocent 1), Palmans, A. R. (Afstudeerdocent 2), Meijer, E. (. (Afstudeerdocent 2) & Meskers, S. C. (Afstudeerdocent 2)

    Scriptie/Masterproef: Master

    Towards non-covalent synthesis: a study on formamidines

    Auteur: van der Woude, P., 29 apr 2020

    Begeleider: Vantomme, G. M. (Afstudeerdocent 1), Meijer, E. (. (Afstudeerdocent 2), Palmans, A. R. (Afstudeerdocent 2) & Abdelmohsen, L. K. (Afstudeerdocent 2)

    Scriptie/Masterproef: Master

    Bestand