• Groene Loper , Building 14, Helix (room STO 3.39)

    5612 AP Eindhoven


  • P.O. Box 513, Department of Biomedical Engineering

    5600 MB Eindhoven



Introductie / missie

At the protein engineering group we develop new proteins for applications in therapy and diagnosis, while critically testing our understanding of protein function.

Highlighted phrase

Beyond the already impressive functional diversity of natural proteins

Over de organisatie

Our group operates at the interface of chemical biology and synthetic biology. Combining protein engineering and DNA nanotechnology, we develop intelligent biomolecular sensors and switches for applications in intracellular imaging, optogenetics, point-of-care diagnostics and antibody-based therapies. An important research theme is to develop generic engineering concepts for the development of protein-based switches, which include fluorescent sensors for intracellular imaging of metal ions, photo-switchable proteins, and protein-based sensors for antibody detection and actuation. We have an active policy of sharing our protein building blocks by depositing our plasmids to AddGene and promote their use by writing dedicated protocols and tutorial reviews. In education, our main goal is to train bachelor, masters and PhD students to become creative biomolecular engineers and independent critical scientists.

Vingerafdruk Duik in de onderzoeksthema's waar Protein Engineering actief is. Deze onderwerplabels komen voort uit het werk van deze leden van de organisatie. Samen vormen ze een unieke vingerafdruk.

Sensors Chemische stoffen
Proteins Chemische stoffen
Energy transfer Chemische stoffen
Energy Transfer Medicijnen en Levenswetenschappen
Dendrimers Chemische stoffen
Peptides Chemische stoffen
Antibodies Chemische stoffen
Collagen Chemische stoffen

Netwerk Recente externe samenwerking op landenniveau. Duik in de details door op de stippen te klikken.

Onderzoeksoutput 1996 2019

2 Citaties (Scopus)
35 Downloads (Pure)

DNA-functionalized supramolecular polymers: dynamic multicomponent assemblies with emergent properties

Wijnands, S. P. W., Meijer, E. W. & Merkx, M., 17 jul 2019, In : Bioconjugate Chemistry. 30, 7, blz. 1905-1914 10 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

Open Access
Hybrid systems

DNA origami-based biomolecular organizing platforms

Rosier, B. J. H. M., 12 dec 2019, Eindhoven: Technische Universiteit Eindhoven. 190 blz.

Onderzoeksoutput: ScriptieDissertatie 1 (Onderzoek TU/e / Promotie TU/e)

Open Access
1 Citaat (Scopus)
8 Downloads (Pure)

Elucidating the ordering in self-assembled glycocalyx mimicking supramolecular copolymers in water

Hendrikse, S. I. S., Su, L., Hogervorst, T. P., Lafleur, R. P. M., Lou, X., van der Marel, G. A., Codee, J. D. C. & Meijer, E. W., 4 sep 2019, In : Journal of the American Chemical Society. 141, 35, blz. 13877-13886 10 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access


Engineering protein switches: sensors and regulators for biology and diagnostics

M. Merkx (Ontvanger), 2011

Prijs: ERCStartingWetenschappelijk

Protein Engineering
Synthetic Biology

Exploring the diagnostics market for simple and fast point-of-care antibody detection

M. Merkx (Ontvanger), 2013

Prijs: ERCProof of conceptWetenschappelijk


NWO Vidi Award : Pieces of plastic with biological properties?

P.Y.W. Dankers (Ontvanger), 2016

Prijs: NWOVidiWetenschappelijk

Bearings (structural)

Activiteiten 2009 2009

  • 1 Redactioneel werk

Nature Methods (Tijdschrift)

Jan Vinkenborg (Lid redactieraad)

Activiteit: Types publicaties van collegiale toetsing en redactioneel werkRedactioneel werkWetenschappelijk


Running DNA Like a Computer Could Help You Fight Viruses One Day

Maarten Merkx


1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

DNA computer brings ‘intelligent drugs‘ a step closer

Maarten Merkx


1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar


Bioluminescent sensors for point-of-care diagnostics

Marjo van Hoof (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

FRET and BRET sensors for intracellular imaging

Marjo van Hoof (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)

Protein sensing and actuation using DNA-based molecular circuits

Marjo van Hoof (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager)

Impact: Research Topic/Theme (at group level)


Benzene-1,3,5-tricarboxamides as supramolecular ordering moieties in polymeric materials

Auteur: Mes, T., mei 2007

Begeleider: Palmans, A. (Afstudeerdocent 1), Roosma, J. (Afstudeerdocent 2) & Meijer, B. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Bioactivation of electrospun UPy-based supramolecular polymer meshes: towards an improved treatment of pelvic floor dysfunctions

Auteur: Arts, B., 18 dec 2017

Begeleider: Dankers, P. (Afstudeerdocent 1), Zaccaria, S. (Afstudeerdocent 2) & Meijer, B. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Bioluminescent antibody conjugates for direct detection of analytes in solution

Auteur: van Aalen, E., 28 mrt 2019

Begeleider: Ni, Y. (Afstudeerdocent 1) & Merkx, M. (Afstudeerdocent 2)

Scriptie/masterproef: Master