Moleculaire Biosensoren voor Medische Diagnostiek

  • Groene Loper 19, Flux

    5612 AE Eindhoven

    Nederland

  • P.O.Box 513, Department of Biomedical Engineering & Department of Applied Physics

    5600 MB Eindhoven

    Nederland

Organisatieprofiel

Introductie / missie

The MBx group develops technologies based on micro- and nanoparticles for monitoring patients and for treating diseases. Towards this goal, the unique approach of MBx is to use advanced optical imaging techniques that quantify molecular processes with single molecule resolution within complex biomacromolecular environments.

Highlighted phrase

Quantify molecular processes with single molecule resolution

Over de organisatie

The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.

Single-molecule imaging and manipulation enables measurements with high sensitivity and gives access to molecular characteristics such as variations in space and in time, distributions of kinetic properties, molecular torsion constants, enzymatic activity, and conformational dynamics.

Furthermore, super-resolution microscopies unveil the interactions of nanostructures with living matter and guide the rational design of novel nanomedicines and diagnostic colloidal particles.

The diagnostic potential and fundamental understanding arising from these biophysical methods leads to novel solutions for patient monitoring and patient treatment. From the work in the group a startup company has been created, Helia Biomonitoring (www.heliabiomonitoring.com). Furthermore, the group has founded and organizes SensUs (www.sensus.org), the international student competition in the field of Sensors for Health, which provides students with training in multidisciplinary technological design and entrepreneurship. 

The MBx group is based in the Department of Biomedical Engineering, the Department of Applied Physics, and the Institute for Complex Molecular Systems.

Vingerafdruk Verdiep u in de onderzoeksgebieden waarop Moleculaire Biosensoren voor Medische Diagnostiek actief is. Deze onderwerplabels komen uit het werk van de leden van deze organisatie. Samen vormen ze een unieke vingerafdruk.

  • Netwerk Recente externe samenwerking op landenniveau. Duik in de details door op de stippen te klikken.

    Onderzoeksoutput

    A plasmonic nanotorch: pushing plasmon-enhanched fluorescence for applications in single-molecule enzymology

    Wang, Y., 19 jun 2020, (Geaccepteerd/In druk) Eindhoven: Technische Universiteit Eindhoven.

    Onderzoeksoutput: ScriptieDissertatie 1 (Onderzoek TU/e / Promotie TU/e)

    Coarse-grained modeling of cell division in 3D: influence of density, medium viscosity, and inter-membrane friction on cell growth and nearest neighbor distribution

    Madhikar, P., Astrom, J., Westerholm, J., Baumeier, B. & Karttunen, M., 5 jan 2020, In : Soft Materials.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Continuous small-molecule monitoring with a digital single particle switch

    Yan, J., van Smeden, L., Merkx, M., Zijlstra, P. & Prins, M. W. J., 24 apr 2020, In : ACS Sensors. 5, 4, blz. 1168-1176 9 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • Prijzen

  • NWO Vidi Award : Nano gold illuminates individual enzymes in a living cell

    P. Zijlstra (Ontvanger), 2013

    Prijs: NWOVidiWetenschappelijk

  • Activiteiten

    • 21 Aangemelde presentatie
    • 4 Genodigd spreker
    • 1 Poster presentatie

    Plasmon-enhanced enzymatic turnovers by single metal particles

    Yuyang Wang (Spreker)
    2 okt 2018

    Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk

    Plasmon-enhanced Single-molecule enzymology

    Yuyang Wang (Spreker)
    18 jul 2018

    Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk

    Plasmon-enhanced Single-molecule Enzymology

    Yuyang Wang (Spreker), P. Zijlstra (Deelnemer)
    23 jan 2018

    Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk

    Knipsels

    IBEC and ICMS sign a Memorandum of Understanding on Research Cooperation

    Lorenzo Albertazzi & Vito Conte

    14/02/20

    1 item van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    Impacts

    Particle Actuation for Integrated Biosensing

    Rianne Sanders (Content manager)

    Impact: Research Topic/Theme (at group level)

    Particle Functionalization and Characterization

    Rianne Sanders (Content manager)

    Impact: Research Topic/Theme (at group level)

    Single-Molecule Biosensing

    Rianne Sanders (Content manager)

    Impact: Research Topic/Theme (at group level)

    Scripties/Masterproeven

    (In,Ga)N heterostructures in self-assembled GaN nanowires grown on TiN by molecular beam epitaxy

    Auteur: Goertz, J. J., 2016

    Begeleider: Koenraad, P. M. (Afstudeerdocent 1), Geelhaar, L. (Externe persoon) (Externe coach), Bakkers, E. P. (Afstudeerdocent 2), Nijdam, S. (Afstudeerdocent 2) & Zijlstra, P. (Afstudeerdocent 2)

    Scriptie/masterproef: Master

    Bestand

    A magnetic bead actuator: design and experimental analysis of a sub-microliter actuation device for superparamagnetic beads applicable on biosensing

    Auteur: Derks, R., 2005

    Begeleider: Prins, M. (Afstudeerdocent 1) & Wimberger-Friedl, R. (Externe persoon) (Externe coach)

    Scriptie/masterproef: Master

    Binding kinetics in tethered particle biosensors

    Auteur: Almass, H., 2018

    Begeleider: Ellenbroek, W. G. (Afstudeerdocent 1) & Zijlstra, P. (Afstudeerdocent 2)

    Scriptie/masterproef: Bachelor

    Bestand