Molecular Biosensing for Medical Diagnostics

  • Groene Loper 19, Flux

    5612 AE Eindhoven


  • P.O.Box 513, Department of Biomedical Engineering & Department of Applied Physics

    5600 MB Eindhoven



Introductie / missie

The MBx group develops technologies based on micro- and nanoparticles for monitoring patients and for treating diseases. Towards this goal, the unique approach of MBx is to use advanced optical imaging techniques that quantify molecular processes with single molecule resolution within complex biomacromolecular environments.

Highlighted phrase

Quantify molecular processes with single molecule resolution

Over de organisatie

The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.

Single-molecule imaging and manipulation enables measurements with high sensitivity and gives access to molecular characteristics such as variations in space and in time, distributions of kinetic properties, molecular torsion constants, enzymatic activity, and conformational dynamics.

Furthermore, super-resolution microscopies unveil the interactions of nanostructures with living matter and guide the rational design of novel nanomedicines and diagnostic colloidal particles.

The diagnostic potential and fundamental understanding arising from these biophysical methods leads to novel solutions for patient monitoring and patient treatment. From the work in the group a startup company has been created, Helia Biomonitoring ( Furthermore, the group has founded and organizes SensUs (, the international student competition in the field of Sensors for Health, which provides students with training in multidisciplinary technological design and entrepreneurship. 

The MBx group is based in the Department of Biomedical Engineering, the Department of Applied Physics, and the Institute for Complex Molecular Systems.

Vingerafdruk Duik in de onderzoeksthema's waar Molecular Biosensing for Medical Diagnostics actief is. Deze onderwerplabels komen voort uit het werk van deze leden van de organisatie. Samen vormen ze een unieke vingerafdruk.

Nanoparticles Engineering en materiaalwetenschappen
Molecules Chemische stoffen
nanoparticles Fysica en Astronomie
actuation Fysica en Astronomie
bioinstrumentation Fysica en Astronomie
Biosensors Chemische stoffen
Gold Chemische stoffen
Assays Chemische stoffen

Netwerk Recente externe samenwerking op landenniveau. Duik in de details door op de stippen te klikken.

Onderzoeksoutput 1980 2020

Coarse-grained modeling of cell division in 3D: influence of density, medium viscosity, and inter-membrane friction on cell growth and nearest neighbor distribution

Madhikar, P., Astrom, J., Westerholm, J., Baumeier, B. & Karttunen, M., 5 jan 2020, In : Soft Materials.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Multiplexed continuous biosensing by single-molecule encoded nanoswitches

Lubken, R. M., de Jong, A. M. & Prins, M. W. J., 6 feb 2020, (Ingediend) In : Nano Letters.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademic


Reaching the tumour: nanoscopy study of nanoparticles in the biological environment

Feiner Gracia, N., 23 jan 2020, Eindhoven: Technische Universiteit Eindhoven. 191 blz.

Onderzoeksoutput: ScriptieDissertatie 1 (Onderzoek TU/e / Promotie TU/e)

Open Access


Nanostructured materials
Imaging techniques
Microscopic examination
Drug delivery
Intelligent materials

NWO Vidi Award : Nano gold illuminates individual enzymes in a living cell

P. Zijlstra (Ontvanger), 2013

Prijs: NWOVidiWetenschappelijk

Biochemical Phenomena
Research Personnel

Activiteiten 2010 2018

  • 21 Aangemelde presentatie
  • 4 Genodigd spreker
  • 1 Poster presentatie

Plasmon-enhanced enzymatic turnovers by single metal particles

Yuyang Wang (Spreker)
2 okt 2018

Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk

Plasmon-enhanced Single-molecule enzymology

Yuyang Wang (Spreker)
18 jul 2018

Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk

Plasmon-enhanced Single-molecule Enzymology

Yuyang Wang (Spreker), P. Zijlstra (Deelnemer)
23 jan 2018

Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk


IBEC and ICMS sign a Memorandum of Understanding on Research Cooperation

Lorenzo Albertazzi & Vito Conte


1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar


Particle Actuation for Integrated Biosensing

Rianne Sanders (Content manager)

Impact: Research Topic/Theme (at group level)

Particle Functionalization and Characterization

Rianne Sanders (Content manager)

Impact: Research Topic/Theme (at group level)

Single-Molecule Biosensing

Rianne Sanders (Content manager)

Impact: Research Topic/Theme (at group level)


A magnetic bead actuator: design and experimental analysis of a sub-microliter actuation device for superparamagnetic beads applicable on biosensing

Auteur: Derks, R., 2005

Begeleider: Prins, M. (Afstudeerdocent 1) & Wimberger-Friedl, R. (Externe persoon) (Externe coach)

Scriptie/masterproef: Master

Blood volume regulation during extracorporeal life support (ECLS) and while using an intra-aortic balloon pump (IABP) measured in a mock circulation loop (MCL)

Auteur: Peeters, K., 28 nov 2019

Begeleider: van de Vosse, F. N. (Afstudeerdocent 1), Rutten, M. C. (Afstudeerdocent 2), Bovendeerd, P. H. (Afstudeerdocent 2), Rosalina, T. T. (Afstudeerdocent 2) & de Jong, A. M. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Continuous monitoring of C-reactive protein by particle mobility sensing with single-molecule resolution

Auteur: Buskermolen, A., 31 okt 2019

Begeleider: Merkx, M. (Afstudeerdocent 1), Prins, M. (Afstudeerdocent 2) & Yan, J. (Afstudeerdocent 2)

Scriptie/masterproef: Master