• Groene Loper, Building 15, Gemini-South (room 3.114)

    5612 AP Eindhoven

    Nederland

Organisatieprofiel

Introductie / missie

The human immune system is highly multifaceted and incredibly fascinating. Immune cells typically act in complex microenvironments which has important implications for immunotherapy. The high level of plasticity is achieved by a wide range of signalling molecules, cell types and specialized subtypes. Successful immunotherapy against cancer, auto-immune and infectious diseases is the result of a multitude of cellular interactions within the immune system.

The core challenge of my group is a systems immunology approach to develop and apply innovative engineering tools to study the immune system in health and disease, and to create new or improve existing therapies by enhancing or modulating immune responses.

Highlighted phrase

Innovative tools to study the immune system

Over de organisatie

Much of the heterogeneity that we observe is thought to originate or at least be influenced by signals from the microenvironment. Measuring the influence of environmental factors on cellular heterogeneity and investigating regulatory strategies of cell populations, however, is difficult with traditional methods as they do not give much opportunity for the control or design of the microenvironment. We exploit and develop an innovative single cell technology toolbox to fill the technology gap by enabling the compartmentalization of single cells or small groups of cells in chambers or droplets. This allows for the design of minimal environments under the omission of most external factors that could influence cellular behaviour. Similarly, complex artificial microenvironments can be designed and created to assess the behaviour of single cells in response to e.g. soluble messengers or number of potential interaction partners. With this immune circuit engineering approach, we believe that probing cellular heterogeneity and decoding immune cell-cell or cell-pathogen interactions longitudinally and in great detail will revolutionise the fields of immunology and cellular immunotherapy. Studying immune interactions at the level of individual cells is the only way to unambiguously elucidate which cellular properties correlate with distinct functions to enable the development of improved cellular immunotherapeutic strategies to battle diseases.

Finally, together with the group of prof. Jan van Hest, in the context of Nanomedicine, we aim to boost the field of artificial immunotherapy. We try to design and synthesize artificial antigen presenting cells: vesicles or nanoparticles that carry antigens and can present these to the immune system like their natural counterparts, the DCs. Synthetic cells may prevent or reduce toxicity and side effects of immunotherapy and allow for precise control over cellular activation.

Our highly dynamic and multidisciplinary team combines expertise’s from; immunology, micro-engineering, single cell analysis, physical organic chemistry, immunoassay development and computational modelling.

Vingerafdruk Verdiep u in de onderzoeksgebieden waarop Immunoengineering actief is. Deze onderwerplabels komen uit het werk van de leden van deze organisatie. Samen vormen ze een unieke vingerafdruk.

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    Onderzoeksoutput

    • 10 Tijdschriftartikel
    • 2 Artikel recenseren

    Programmable bivalent peptide-DNA locks for pH-based control of antibody activity

    Engelen, W., Zhu, K., Subedi, N., Idili, A., Ricci, F., Tel, J. & Merkx, M., 22 jan 2020, In : ACS Central Science. 6, 1, blz. 22-31 10 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
    Bestand
  • 1 Citaat (Scopus)
    21 Downloads (Pure)

    An aptamer-based new method for competitive fluorescence detection of exosomes

    Yu, X., He, L., Pentok, M., Yang, H., Yang, Y., Li, Z., He, N., Deng, Y., Li, S., Liu, T., Chen, X. & Luo, H., 7 sep 2019, In : Nanoscale. 11, 33, blz. 15589-15595 7 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • 13 Citaten (Scopus)
    1 Downloads (Pure)

    A pipette-tip based method for seeding cells to droplet microfluidic platforms

    Sinha, N., Subedi, N., Wimmers, F., Soennichsen, M. & Tel, J., 11 feb 2019, In : Journal of Visualized Experiments (JoVE). 144, 10 blz., e57848.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
    Bestand
  • 3 Citaten (Scopus)
    45 Downloads (Pure)

    Prijzen

    Decoding cellular interactions

    Tel, Jurjen (Ontvanger), 2018

    Prijs: ERCStartingWetenschappelijk

  • Knipsels

    Random fraction of specialized immune cells leads the charge in battling invaders

    J. Tel

    29/08/18

    1 item van Media-aandacht

    Pers / media: Vakinhoudelijk commentaar

    Impacts

    Immune circuit construction using multi-layer microfluidic designs

    Jurjen Tel (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager) & Moniek Looijenga (Content manager)

    Impact: Research Topic/Theme (at group level)

    Single-cell analysis of immune cells using droplet-based microfluidics

    Jurjen Tel (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager) & Moniek Looijenga (Content manager)

    Impact: Research Topic/Theme (at group level)

    Scripties/Masterproeven

    Probing macrophage plasticity and heterogeneity using microfluidic single-cell encapsulation and multicolor flow cytometry

    Auteur: Tiemeijer, B., 25 apr 2019

    Begeleider: Tel, J. (Afstudeerdocent 1), Smits, A. (Afstudeerdocent 2) & Subedi, N. (Afstudeerdocent 2)

    Scriptie/Masterproef: Master

    The effect of acidosis on osteoclastic bone resorption in 3D in vitro

    Auteur: Sleddens, M., 31 aug 2017

    Begeleider: Ito, K. (Afstudeerdocent 1), Hofmann Boss, S. (Afstudeerdocent 2), Tel, J. (Afstudeerdocent 2) & Remmers, S. (Afstudeerdocent 2)

    Scriptie/Masterproef: Master

    The Warburg effect: a tissue scale phenomenon

    Auteur: Haakma, J., 20 jun 2019

    Begeleider: Hilbers, P. (Afstudeerdocent 1), van Riel, N. (Afstudeerdocent 2) & Tel, J. (Afstudeerdocent 2)

    Scriptie/Masterproef: Master