Projecten per jaar
Organisatieprofiel
Introductie / missie
Our mission is to make things move at small scales: fluids, particles, molecules, solid structures. We do this by carrying out research in our Microfab/lab, where we develop innovative technological concepts and fabrication methods to create novel microfluidic devices and microactuators, serving a wide range of applications.
Highlighted phrase
We make things move at small scales!
Over de organisatie
In microfluidic systems, active control of fluids and species is essential. Examples are fluid pumping, mixing, mechanical actuation, sorting of cells and particles, and biomolecule capture for diagnostics. We develop and apply micro-actuators, responsive surfaces, and magnetic bead actuation systems, to realize these functions. Our approaches are often biologically inspired, translating principles from nature into technological innovations.
As an important application of our microfluidic systems, and in collaboration with biological, biomedical, and clinical groups, we develop biomedical microdevices to study and understand the behavior of cells, tissues, and organs. This work is aimed at learning about health and disease, and eventually developing novel therapies and medicines. Specifically, we develop organs-on-chips as in-vitro disease models focusing on cancer, we study mechanical properties of single cells, and we develop technologies for in-vitro diagnostics. In addition, we develop biomedical devices that can be applied to treat patients non-invasively, such as a glaucoma eye implant.
We also develop new concepts for microactuators that combine electrical, optical and/or mechanical functionalities, for other applications, from lithography machines to new display principles to air quality monitoring to microrobotics.
Vingerafdruk
Netwerk
Profielen
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Eva A. van Aalen
- Mechanical Engineering, Group Den Toonder - Onderzoeker
- Biomedical Engineering, Protein Engineering - Onderzoeker
Persoon: OWP : Docent / Onderzoeker
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Liesbeth van Ballegooij
- Mechanical Engineering, Group Den Toonder - Secretaresse
- Mechanical Engineering, Microsystems - Secretaresse
Persoon: Secr. : Secretaresse
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Zhiwei Cui
- Mechanical Engineering, Microsystems - Promovendus
- Mechanical Engineering, Group Den Toonder - Promovendus
Persoon: Prom. : Promovendus
projecten
- 1 Afgelopen
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Magnetic control of micro-particles and integrated micro-actuators for high precision handheld diagnostics
den Toonder, J. M. J. & Shanko, E.
1/11/16 → 31/10/20
Project: Onderzoek direct
Onderzoeksoutput
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A micropillar array-based microfluidic chip for label-free separation of circulating tumor cells: The best micropillar geometry?
Rahmanian, M., Sartipzadeh Hematabad, O., Askari, E., Shokati, F., Bakhshi, A., Moghadam, S., Olfatbakhsh, A., Al Sadat Hashemi, E., Khorsand Ahmadi, M., Morteza Naghib, S., Sinha, N., Tel, J., Eslami Amirabadi, H., den Toonder, J. M. J. & Majidzadeh-A, K., mei 2023, In: Journal of Advanced Research. 47, X, blz. 105-121 17 blz.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand3 Citaten (Scopus) -
A versatile artificial skin platform for sweat sensor development
Moonen, E. J. M., ul Islam, T., van Kemenade, S., Pelssers, E., Heikenfeld, J. & den Toonder, J. M. J., 7 mei 2023, In: Lab on a Chip. 23, 9, blz. 2268-2275 8 blz.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand2 Downloads (Pure) -
Engineering a Scalable and Orthogonal Platform for Synthetic Communication in Mammalian Cells
Makri Pistikou, A-M., Cremers, G. A. O., Nathalia, B. L., Bögels, B., de Dreu, A., Bezembinder, M., Eijkens, B. V., Stassen, O. M. J. A., Bouten, C. V. C., Merkx, M., Jerala, R. & de Greef, T. F. A., 2023, (Ingediend) In: Nature Communications. XX, XOnderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic
Datasets
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Microfluidic Models of Metastasis: In vitro approaches to study the tumor microenvironment - supplementary design and video files
Sleeboom, J. J. F. (Ontwerper), Sahlgren, C. M. (Ontwerper) & den Toonder, J. M. J. (Ontwerper), 4TU.Centre for Research Data, 21 aug. 2020
DOI: 10.4121/uuid:08ac69b6-6430-4ffa-a33e-40da88821dc6
Dataset
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Source data for the publication: Anti-Biofouling and Self-Cleaning Surfaces Featured with Magnetic Artificial Cilia
Zhang, S. (Bijdrager), Zuo, P. (Bijdrager), Wang, Y. (Bijdrager), Onck, P. (Bijdrager), den Toonder, J. M. J. (Bijdrager) & den Toonder, J. M. J. (Bijdrager), 4TU.Centre for Research Data, 30 mei 2022
DOI: 10.4121/19915330
Dataset
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Source data for the publication: Metachronal actuation of microscopic magnetic artificial cilia generates strong microfluidic pumping
Zhang, S. (Bijdrager), Cui, Z. (Bijdrager), Wang, Y. (Bijdrager) & den Toonder, J. M. J. (Bijdrager), 4TU.Centre for Research Data, 30 mei 2022
DOI: 10.4121/19915450
Dataset
Prijzen
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Famelab Heat 2021(Audience's choice award)
Jouy Bar, Mohammad (Ontvanger), 29 apr. 2021
Prijs: Anders › Werk, activiteit of publicatie gerelateerde prijzen (lifetime, best paper, poster etc.) › Wetenschappelijk
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FameLab National Final 2021
Jouy Bar, Mohammad (Ontvanger), 1 jun. 2021
Prijs: Anders › Werk, activiteit of publicatie gerelateerde prijzen (lifetime, best paper, poster etc.) › Wetenschappelijk
Knipsels
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Research on Gels Research Published by a Researcher at Eindhoven University of Technology (Single Hydrogel Particle Mechanics and Dynamics Studied by Combining Capillary Micromechanics with Osmotic Compression)
22/03/23
1 item van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
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Sweet way to study blood vessels near tumors 4 April
4/04/22
2 items van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
Scripties/Masterproeven
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A microfluidic platform for multiplexed continuous monitoring using bioluminescent immunoassays
Auteur: Jansen, T. P. A., 2022Begeleider: Rosier, B. J. H. M. (Afstudeerdocent 1), van Aalen, E. A. (Afstudeerdocent 2) & Merkx, M. (Afstudeerdocent 2)
Scriptie/Masterproef: Master
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Analysis of liquid crystal actuation towards a light-driven amphibious soft microrobot
Auteur: van Beek, J. C., 19 jan. 2021Begeleider: den Toonder, J. M. J. (Afstudeerdocent 1), Schenning, A. P. H. J. (Afstudeerdocent 2), Pilz Da Cunha, M. (Afstudeerdocent 2) & Wang, Y. (Afstudeerdocent 2)
Scriptie/Masterproef: Master
Bestand -
An integrated approach to study the aerotaxis of breast cancer cells in a 3D environment using an oxygen diffusion chip
Auteur: Selhorst, L., 27 aug. 2020Begeleider: Sleeboom, J. J. F. (Afstudeerdocent 1) & Sahlgren, C. M. (Afstudeerdocent 2)
Scriptie/Masterproef: Master