We develop compartmentalization strategies to construct micro- and nano-capsules for application in nanomedicine and artificial cell research.

Creating minuscule compartments with life-like features

In our research we combine techniques from protein engineering, polymer chemistry and bioconjugation approaches to create particles with bioactive properties. In the field of nanomedicine, we design smart delivery vehicles that for example cross the blood brain barrier or are used in cancer therapy. We also use nanoparticles as scaffolds for vaccine development. In the field of artificial cell research, we aim to create responsive smart compartments that mimic the behavior of living cells. For instance, we develop nanoreactors that can be incorporated as artificial organelles in living cells, to complement or affect cellular processes.

With advanced synthetic techniques and assembly methods, we can construct particles with control over size, shape, surface charge and functionality. In the field of nanomedicine, these particles are employed in treating brain related (metabolic) diseases, ophthalmology, cancer research and bacterial vaccine development. This is pursued in collaboration with our (international) partners. In the field of artificial cell research, we construct capsules with life-like properties, such as metabolism, organelle-mimetic behavior and cell growth and motility. We are part of the Institute for Complex Molecular Systems (ICMS) and of the Research Center for Functional Molecular Systems (FMS), brought together to complete a single grand challenge: the construction of functional life-like molecular systems.