Onderzoeksoutput per jaar
Introductie / missie
We develop compartmentalization strategies to construct micro- and nano-capsules for application in nanomedicine and artificial cell research.
Creating minuscule compartments with life-like features
Over de organisatie
In our research we combine techniques from protein engineering, polymer chemistry and bioconjugation approaches to create particles with bioactive properties. In the field of nanomedicine, we design smart delivery vehicles that for example cross the blood brain barrier or are used in cancer therapy. We also use nanoparticles as scaffolds for vaccine development. In the field of artificial cell research, we aim to create responsive smart compartments that mimic the behavior of living cells. For instance, we develop nanoreactors that can be incorporated as artificial organelles in living cells, to complement or affect cellular processes.
With advanced synthetic techniques and assembly methods, we can construct particles with control over size, shape, surface charge and functionality. In the field of nanomedicine, these particles are employed in treating brain related (metabolic) diseases, ophthalmology, cancer research and bacterial vaccine development. This is pursued in collaboration with our (international) partners. In the field of artificial cell research, we construct capsules with life-like properties, such as metabolism, organelle-mimetic behavior and cell growth and motility. We are part of the Institute for Complex Molecular Systems (ICMS) and of the Research Center for Functional Molecular Systems (FMS), brought together to complete a single grand challenge: the construction of functional life-like molecular systems.
Persoon: Prom. : Promovendus
Persoon: UD : Universitair Docent
CD44-targeted vesicles encapsulating granzyme B as artificial killer cells for potent inhibition of human multiple myeloma in miceZhong, Y., Meng, F., Zhang, W., Li, B., van Hest, J. C. M. & Zhong, Z., 10 apr 2020, In : Journal of Controlled Release. 320, blz. 421-430 10 blz.
Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Onderzoeksoutput: Scriptie › Dissertatie 1 (Onderzoek TU/e / Promotie TU/e)
Prijs: NWO › Zwaartekracht › Wetenschappelijk
Activiteiten per jaar
1 item van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
Development of Fischer Tropsch foam catalyst and reactor development: diffusion limitations for FTS foam catalystAuteur: van der Linden, C., 1 sep 2017
Begeleider: de Martino, M. (Afstudeerdocent 1)