Projecten per jaar
Organisatieprofiel
Introductie / missie
We develop compartmentalization strategies to construct micro- and nano-capsules for application in nanomedicine and artificial cell research.
Highlighted phrase
Creating minuscule compartments with life-like features
Organisatieprofiel
In our research we combine techniques from protein engineering, polymer chemistry and bioconjugation approaches to create particles with bioactive properties. In the field of nanomedicine, we design smart delivery vehicles that for example cross the blood brain barrier or are used in cancer therapy. We also use nanoparticles as scaffolds for vaccine development. In the field of artificial cell research, we aim to create responsive smart compartments that mimic the behavior of living cells. For instance, we develop nanoreactors that can be incorporated as artificial organelles in living cells, to complement or affect cellular processes.
With advanced synthetic techniques and assembly methods, we can construct particles with control over size, shape, surface charge and functionality. In the field of nanomedicine, these particles are employed in treating brain related (metabolic) diseases, ophthalmology, cancer research and bacterial vaccine development. This is pursued in collaboration with our (international) partners. In the field of artificial cell research, we construct capsules with life-like properties, such as metabolism, organelle-mimetic behavior and cell growth and motility. We are part of the Institute for Complex Molecular Systems (ICMS) and of the Research Center for Functional Molecular Systems (FMS), brought together to complete a single grand challenge: the construction of functional life-like molecular systems.
Vingerafdruk
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Profielen
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Loai K.E.A. Abdelmohsen
- Chemical Engineering and Chemistry, Bio-Organic Chemistry - Universitair Docent
- ICMS Core - Universitair Docent
Persoon: UD : Universitair Docent
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Shree Bagchi
- Chemical Engineering and Chemistry, Bio-Organic Chemistry - Promovendus
Persoon: Prom. : Promovendus
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Alan Białek
- Chemical Engineering and Chemistry, Bio-Organic Chemistry - Promovendus
Persoon: Prom. : Promovendus
projecten
- 1 Afgelopen
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TKI-LSH EUREKA COVID-19 Network Call application form 2020 Solutions for the next human high-impact pandemic
van Hest, J. C. M. (Project Manager), van Hest, J. C. M. (Projectmedewerker) & Le, H. T. D. (Projectmedewerker)
1/12/20 → 30/11/23
Project: Onderzoek direct
Onderzoeksoutput
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A modular nanoparticle vaccine platform for tailored antigen and adjuvant delivery
de Dreu, A., Schrijver, D. P., Cremers, G. A. O., de Bruin, K., Vos, B. N., Anbergen, T., van Elsas, Y., Versteeg, I., Zwolsman, R., Deckers, J., Timmers, M., Roelofs, S., Darwish, Y., van der Staak, M., Priem, B., Maas, R. J. F., de Leeuw, P., Ros, G., Bartelet, B. & Hendrikx, M. & 14 anderen, , 2025, (Ingediend) In: Nature Nanotechnology. XX, XOnderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
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A polymer nanogel-based therapeutic nanovaccine for prophylaxis and direct treatment of tumors via a full-cycle immunomodulation
Guo, Y., Wang, Z., Li, G., Zhan, M., Xiao, T., Wang, J., van Hest, J. C. M. (Corresponding author), Shi, X. (Corresponding author) & Shen, M. (Corresponding author), jan. 2025, In: Bioactive Materials. 43, blz. 129-144 16 blz.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand3 Citaten (Scopus)40 Downloads (Pure) -
Author Correction: Cytoskeleton-functionalized synthetic cells with life-like mechanical features and regulated membrane dynamicity (Nature Chemistry, (2025), 10.1038/s41557-024-01697-5)
Novosedlik, S., Reichel, F., van Veldhuisen, T., Li, Y., Wu, H., Janssen, H. (Corresponding author), Guck, J. & van Hest, J. (Corresponding author), mrt. 2025, In: Nature Chemistry. 17, 3, blz. 457 1 blz.Onderzoeksoutput: Bijdrage aan tijdschrift › Commentaar/Brief aan de redacteur › Academic › peer review
Open AccessBestand2 Downloads (Pure)
Uitrusting
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Molecular Science and Technology (MST)
van Dongen, J. L. J. (Manager)
Bio-Organic ChemistryUitrusting/faciliteit: Onderzoekslaboratorium
Datasets
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Data underlying the research of Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N-Acetylneuraminate Lyase in a Continuous Flow Reactor
Bloemendal, V. R. L. J. (Ontwerper), Moons, S. J. (Ontwerper), Heming, J. J. A. (Bijdrager), Chayoua, M. (Ontwerper), Niesink, O. (Ontwerper), van Hest, J. C. M. (Ontwerper), Boltje, T. J. (Ontwerper) & Rutjes, F. P. J. T. (Ontwerper), 4TU.Centre for Research Data, 25 apr. 2019
DOI: 10.4121/uuid:74547c17-9760-4e07-b901-a6d9cd21d092, https://data.4tu.nl/articles/_/12704774/1
Dataset
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Replication Data for: Urease-powered nanobots for radionuclide bladder cancer therapy
Simó, C. (Ontwerper), Serra-Casablancas, M. (Ontwerper), Hortelaõ, A. C. (Bijdrager), Di Carlo, V. (Ontwerper), Guallar-Garrido, S. (Bijdrager), Rabanal, R. M. (Ontwerper), Ramos-Cabrer, P. (Ontwerper), Yagüe, B. (Ontwerper), Aguado, L. (Ontwerper), Bardia, L. (Ontwerper), Tosi, S. (Ontwerper), Gómez-Vallejo, V. (Bijdrager), Martín, A. (Bijdrager), Patiño, T. (Bijdrager), Julián, E. (Ontwerper), Colombelli, J. (Ontwerper), Llop, J. (Ontwerper) & Sánchez, S. (Ontwerper), CORA Repositori de Dades de Recerca, 29 okt. 2024
DOI: 10.34810/data1774, https://dataverse.csuc.cat/citation?persistentId=doi:10.34810/data1774
Dataset
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Cryo-TEM raw data underlying the publication: Polymersomes with splenic avidity target red pulp myeloid cells for cancer immunotherapy
Wauters, A. C. (Ontwerper), Scheerstra, J. F. (Ontwerper) & van Hest, J. C. M. (Ontwerper), 4TU.Centre for Research Data, 31 jul. 2024
DOI: 10.4121/4f8c02c7-9787-435c-a9b2-1adc3af5dd22, https://data.4tu.nl/datasets/4f8c02c7-9787-435c-a9b2-1adc3af5dd22 en nog één link, https://data.4tu.nl/datasets/4f8c02c7-9787-435c-a9b2-1adc3af5dd22/1 (minder tonen)
Dataset
Prijzen
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Artificial endosymbiosis
van Hest, J. C. M. (Ontvanger), 2015
Prijs: ERC › Advanced › Wetenschappelijk
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Research Center for Functional Molecular Systems
Meijer, E. W. (Ontvanger), van Hest, J. C. M. (Ontvanger), Brunsveld, L. (Ontvanger), Janssen, R. A. J. (Ontvanger) & Sijbesma, R. P. (Ontvanger), 2013
Prijs: NWO › Zwaartekracht › Wetenschappelijk
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University of Oxford
Mason, A. (Bezoekende onderzoeker) & Bayley, H. (Bezoekende docent)
2019 → …Activiteit: Types bezoeken aan een externe instelling › Bezoek externe academische instelling › Wetenschappelijk
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Dutch Peptide Symposium - 2015
Welzen, P. (Organisator)
27 mei 2015Activiteit: Types deelname aan of organisatie van een evenement › Congres › Wetenschappelijk
Knipsels
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Artificial Cell Communication: Protein on Demand
Hazegh Nikroo, A., Altenburg, W. J., van Veldhuisen, T. W., Brunsveld, L. & van Hest, J. C. M.
17/10/24
2 items van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
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Reports Outline Pharmaceutics Research from Eindhoven University of Technology (Inherently Fluorescent Peanut-Shaped Polymersomes for Active Cargo Transportation)
Luo, Y., van Hest, J. C. M., Shao, J. & Abdelmohsen, L. K. E. A.
7/08/23
1 item van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
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Dalian University of Technology Reports Findings in Nanocarriers (pH-Mediated Mucus Penetration of Zwitterionic Polydopamine-Modified Silica Nanoparticles)
4/08/23
1 item van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
Scripties/Masterproeven
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A study on the supramolecular folding behavior of glucose-functionalized polymers in water
Heidendael, L. C. H. (Auteur), Varela Aramburu, S. (Afstudeerdocent 1), Palmans, A. R. A. (Afstudeerdocent 2) & Meijer, E. W. (Afstudeerdocent 2), 26 feb. 2020Scriptie/Masterproef: Master
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Behaviour and morphology of self-assemblies of pH-responsive polyurethane ionomers
Song, S. (Auteur), Voets, I. K. (Afstudeerdocent 1), Sahebali, S. (Afstudeerdocent 2), Tuinier, R. (Afstudeerdocent 2) & Sijbesma, R. P. (Afstudeerdocent 2), 29 nov. 2017Scriptie/Masterproef: Master
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Biodegradable Nanomotors as an Anticancer Drug Delivery System
Koppelaar, E. (Auteur), Li, Y. (Afstudeerdocent 1) & van Hest, J. C. M. (Afstudeerdocent 2), 25 mei 2023Scriptie/Masterproef: Master