• Postbus 513, Helix Building

    5600 MB Eindhoven

    Nederland

  • De Groene Loper 3, Helix Building (STO 3.39)

    5612 AE Eindhoven

    Nederland

Organisatieprofiel

Introductie / missie

We develop compartmentalization strategies to construct micro- and nano-capsules for application in nanomedicine and artificial cell research.

Highlighted phrase

Creating minuscule compartments with life-like features

Over de organisatie

In our research we combine techniques from protein engineering, polymer chemistry and bioconjugation approaches to create particles with bioactive properties. In the field of nanomedicine, we design smart delivery vehicles that for example cross the blood brain barrier or are used in cancer therapy. We also use nanoparticles as scaffolds for vaccine development. In the field of artificial cell research, we aim to create responsive smart compartments that mimic the behavior of living cells. For instance, we develop nanoreactors that can be incorporated as artificial organelles in living cells, to complement or affect cellular processes.

With advanced synthetic techniques and assembly methods, we can construct particles with control over size, shape, surface charge and functionality. In the field of nanomedicine, these particles are employed in treating brain related (metabolic) diseases, ophthalmology, cancer research and bacterial vaccine development. This is pursued in collaboration with our (international) partners. In the field of artificial cell research, we construct capsules with life-like properties, such as metabolism, organelle-mimetic behavior and cell growth and motility. We are part of the Institute for Complex Molecular Systems (ICMS) and of the Research Center for Functional Molecular Systems (FMS), brought together to complete a single grand challenge: the construction of functional life-like molecular systems.

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Onderzoeksoutput 2008 2020

Peroxiredoxin proteins as building blocks for nanotechnology

Conroy, F. & Yewdall, A., 2020, Protein Nanotechnology. Gerard, J. & Domigan, L. (redactie). Humana: Springer, blz. 39-54 16 blz. (Methods in Molecular Biology; vol. 2073)

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukAcademicpeer review

Peroxiredoxins
Nanotechnology
Proteins
Transmission Electron Microscopy
Centrifugation

Adaptive polymeric assemblies for applications in biomimicry and nanomedicine

Altay, Y., Che, H., Cao, S., Abdelmohsen, L. & van Hest, J., 23 okt 2019, In : Biomacromolecules. 20, 11, blz. 4053-4064 12 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Medical nanotechnology
Nanostructured materials
Self assembly
Intelligent networks
Complex networks

Adaptive polymersome nanoreactors

Che, H. & van Hest, J. C. M., 1 sep 2019, In : ChemNanoMat. 5, 9, blz. 1092-1109

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Nanoreactors
Medical nanotechnology
Adaptive systems

Uitrusting

Molecular Science and Technology (MST)

Joost van Dongen (Manager)

Bio-Organic Chemistry

Uitrusting/faciliteit: Onderzoekslaboratorium

Prijzen

Artificial endosymbiosis

Jan van Hest (Ontvanger), 2015

Prijs: ERCAdvancedWetenschappelijk

symbiosis
organelles
cells
synthetic biology
uptake mechanisms

Checkpoint NANO

Willem Mulder (Ontvanger), nov 2018

Prijs: ERCConsolidatorWetenschappelijk

Precision Medicine
Immune System
Research
Pharmaceutical Preparations
Immunotherapy

Research Center for Functional Molecular Systems

Bert Meijer (Ontvanger), Jan van Hest (Ontvanger), Luc Brunsveld (Ontvanger), Rene Janssen (Ontvanger) & Rint Sijbesma (Ontvanger), 2013

Prijs: NWOZwaartekrachtWetenschappelijk

Netherlands
selection procedure
Ministry of Education
funding
organization

Activiteiten 2015 2015

Dutch Peptide Symposium - 2015

Pascal Welzen (Organisator)
27 mei 2015

Activiteit: Types deelname aan of organisatie van een evenementCongresWetenschappelijk

Scripties/masterproeven

Development of Fischer Tropsch foam catalyst and reactor development: diffusion limitations for FTS foam catalyst

Auteur: van der Linden, C., 1 sep 2017

Begeleider: de Martino, M. (Afstudeerdocent 1)

Scriptie/masterproef: Master

Bestand

Development of reduction responsive polymersomes for controlled drug delivery

Auteur: Stam, R., 13 nov 2018

Begeleider: Pijpers, I. (Afstudeerdocent 1), van Hest, J. (Afstudeerdocent 2), Brunsveld, L. (Afstudeerdocent 2) & Abdelmohsen, L. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Measuring all three vitamin D metabolites on the LC-MS/MS: effects of vitamin D supplementation in pre-dialysis patients

Auteur: Verbon, I., 27 nov 2017

Begeleider: van Dongen, J. (Afstudeerdocent 1) & Schmitz, E. (Afstudeerdocent 2)

Scriptie/masterproef: Master