Projecten per jaar
Organisatieprofiel
Introductie / missie
We develop compartmentalization strategies to construct micro- and nano-capsules for application in nanomedicine and artificial cell research.
Highlighted phrase
Creating minuscule compartments with life-like features
Over de organisatie
In our research we combine techniques from protein engineering, polymer chemistry and bioconjugation approaches to create particles with bioactive properties. In the field of nanomedicine, we design smart delivery vehicles that for example cross the blood brain barrier or are used in cancer therapy. We also use nanoparticles as scaffolds for vaccine development. In the field of artificial cell research, we aim to create responsive smart compartments that mimic the behavior of living cells. For instance, we develop nanoreactors that can be incorporated as artificial organelles in living cells, to complement or affect cellular processes.
With advanced synthetic techniques and assembly methods, we can construct particles with control over size, shape, surface charge and functionality. In the field of nanomedicine, these particles are employed in treating brain related (metabolic) diseases, ophthalmology, cancer research and bacterial vaccine development. This is pursued in collaboration with our (international) partners. In the field of artificial cell research, we construct capsules with life-like properties, such as metabolism, organelle-mimetic behavior and cell growth and motility. We are part of the Institute for Complex Molecular Systems (ICMS) and of the Research Center for Functional Molecular Systems (FMS), brought together to complete a single grand challenge: the construction of functional life-like molecular systems.
Vingerafdruk
Netwerk
Profielen
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Loai K.E.A. Abdelmohsen
- Chemical Engineering and Chemistry, Bio-Organic Chemistry - Universitair Docent
- ICMS Core - Universitair Docent
Persoon: UD : Universitair Docent
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Wouter P. van den Akker
- Chemical Engineering and Chemistry, Bio-Organic Chemistry - Promovendus
Persoon: Prom. : Promovendus
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Ralf A.A. Bovee
- Chemical Engineering and Chemistry, Bio-Organic Chemistry - Medew. Onderwijs en Onderzoek
Persoon: OBP : Ondersteunend en Beheerspersoneel
projecten
- 1 Actief
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TKI-LSH EUREKA COVID-19 Network Call application form 2020 Solutions for the next human high-impact pandemic
van Hest, J. C. M., van Hest, J. C. M. & Le, H. T. D.
1/12/20 → 30/11/23
Project: Onderzoek direct
Onderzoeksoutput
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Achieving Control in Micro-/Nanomotor Mobility
Fusi, A. D., Li, Y., Llopis-Lorente, A., Patiño, T., van Hest, J. C. M. & Abdelmohsen, L., 26 jan. 2023, In: Angewandte Chemie - International Edition. 62, 5, 16 blz., e202214754.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand1 Citaat (Scopus)25 Downloads (Pure) -
Analysis of Neuron–Specific enolase isozymes in human serum using immunoaffinity purification and liquid chromatography–tandem mass spectrometry quantification
Genet, S. A. A. M., Wolfs, J. R. E., Vu, C. B. A. K., Wolter, M., Broeren, M. A. C., van Dongen, J., Brunsveld, L., Scharnhorst, V. & van de Kerkhof, D., 1 mei 2023, In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1223, 7 blz., 123701.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand4 Downloads (Pure) -
Chemical Cascading Between Polymersomal Nanoreactor Populations
Altay, Y., Llopis-Lorente, A., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., jan. 2023, In: Macromolecular Chemistry and Physics. 224, 1, 5 blz., 2200269.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand15 Downloads (Pure)
Uitrusting
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Molecular Science and Technology (MST)
J.L.J. van Dongen (Manager)
Bio-Organic ChemistryUitrusting/faciliteit: Onderzoekslaboratorium
Datasets
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Molecular Recognition: Comparative Study of a Tunable Host-Guest System by Using a Fluorescent Model System and Collision-Induced Dissociation Mass Spectrometry on Dendrimers
Nielsen, C. B. (Bijdrager), Christensen, J. B. (Bijdrager), Broeren, M. A. C. (Bijdrager), Meijer, E. W. (Bijdrager), van Dongen, J. L. J. (Bijdrager), Pittelkow, M. (Bijdrager) & van Genderen, M. H. P. (Bijdrager), SupraBank, 2022
DOI: 10.34804/supra.20210928167
Dataset
Prijzen
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Artificial endosymbiosis
van Hest, Jan C.M. (Ontvanger), 2015
Prijs: ERC › Advanced › Wetenschappelijk
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Checkpoint NANO
Mulder, Willem J.M. (Ontvanger), nov. 2018
Prijs: ERC › Consolidator › Wetenschappelijk
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Research Center for Functional Molecular Systems
Meijer, E.W. (Bert) (Ontvanger), van Hest, Jan C.M. (Ontvanger), Brunsveld, Luc (Ontvanger), Janssen, René A.J. (Ontvanger) & Sijbesma, Rint P. (Ontvanger), 2013
Prijs: NWO › Zwaartekracht › Wetenschappelijk
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University of Oxford
Alexander Mason (Bezoekende onderzoeker) & Hagan Bayley (Bezoekende docent)
2019 → …Activiteit: Types bezoeken aan een externe instelling › Bezoek externe academische instelling › Wetenschappelijk
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Dutch Peptide Symposium - 2015
Pascal Welzen (Organisator)
27 mei 2015Activiteit: Types deelname aan of organisatie van een evenement › Congres › Wetenschappelijk
Knipsels
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Eindhoven University of Technology Reports Findings in Nanospheres (Nonlinear Transient Permeability in pH-Responsive Bicontinuous Nanospheres)
11/04/23
1 item van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
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Dalian University of Technology Reports Findings in Nanoparticles (Mucus Penetration of Surface-Engineered Nanoparticles in Various pH Microenvironments)
14/02/23
1 item van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
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Synthetic cells communicate with organic cells
4/01/23
1 item van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
Scripties/Masterproeven
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A study on the supramolecular folding behavior of glucose-functionalized polymers in water
Auteur: Heidendael, L. C. H., 26 feb. 2020Begeleider: Varela Aramburu, S. (Afstudeerdocent 1), Palmans, A. R. A. (Afstudeerdocent 2) & Meijer, E. W. (Afstudeerdocent 2)
Scriptie/Masterproef: Master
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Behaviour and morphology of self-assemblies of pH-responsive polyurethane ionomers
Auteur: Song, S., 29 nov. 2017Begeleider: Voets, I. K. (Afstudeerdocent 1), Sahebali, S. (Afstudeerdocent 2), Tuinier, R. (Afstudeerdocent 2) & Sijbesma, R. P. (Afstudeerdocent 2)
Scriptie/Masterproef: Master
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Characterisation and employment of PylD-loaded nanoreactors
Auteur: Blezer, K. J. R., 28 mei 2020Begeleider: Timmermans, S. B. P. E. (Afstudeerdocent 1) & Hest, van, J. C. M. (Afstudeerdocent 2)
Scriptie/Masterproef: Master