• Postbus 513, Helix Building

    5600 MB Eindhoven

    Nederland

  • De Groene Loper 3, Helix Building (STO 3.39)

    5612 AE Eindhoven

    Nederland

Organisatieprofiel

Introductie / missie

We develop compartmentalization strategies to construct micro- and nano-capsules for application in nanomedicine and artificial cell research.

Highlighted phrase

Creating minuscule compartments with life-like features

Over de organisatie

In our research we combine techniques from protein engineering, polymer chemistry and bioconjugation approaches to create particles with bioactive properties. In the field of nanomedicine, we design smart delivery vehicles that for example cross the blood brain barrier or are used in cancer therapy. We also use nanoparticles as scaffolds for vaccine development. In the field of artificial cell research, we aim to create responsive smart compartments that mimic the behavior of living cells. For instance, we develop nanoreactors that can be incorporated as artificial organelles in living cells, to complement or affect cellular processes.

With advanced synthetic techniques and assembly methods, we can construct particles with control over size, shape, surface charge and functionality. In the field of nanomedicine, these particles are employed in treating brain related (metabolic) diseases, ophthalmology, cancer research and bacterial vaccine development. This is pursued in collaboration with our (international) partners. In the field of artificial cell research, we construct capsules with life-like properties, such as metabolism, organelle-mimetic behavior and cell growth and motility. We are part of the Institute for Complex Molecular Systems (ICMS) and of the Research Center for Functional Molecular Systems (FMS), brought together to complete a single grand challenge: the construction of functional life-like molecular systems.

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Onderzoeksoutput 2008 2019

Adaptive polymersome nanoreactors

Che, H. & van Hest, J. C. M., 27 mei 2019, In : ChemNanoMat.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Nanoreactors
Medical nanotechnology
Adaptive systems

A revised modular approach to (–)-trans-Δ 8 -THC and derivatives through late-stage Suzuki–Miyaura cross-coupling reactions

Bloemendal, V. R. L. J., Sondag, D., Elferink, H., Boltje, T. J., van Hest, J. C. M. & Rutjes, F. P. J. T., 31 mrt 2019, In : European Journal of Organic Chemistry. 2019, 12, blz. 2289-2296 8 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
thermohaline circulation
Dronabinol
cross coupling
Derivatives
Scaffolds

Biomorphic engineering of multifunctional polylactide stomatocytes toward therapeutic nano-red blood cells

Shao, J., Pijpers, I. A. B., Cao, S., Williams, D. S., Yan, X., Li, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 1 jan 2019, In : Advanced Science. 6, 5, 8 blz., 1801678

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
erythrocytes
Blood
Erythrocytes
Cells
engineering

Uitrusting

Molecular Science and Technology (MST)

Joost van Dongen (Manager)

Bio-Organic Chemistry

Uitrusting/faciliteit: Onderzoekslaboratorium

Prijzen

Artificial endosymbiosis

Jan van Hest (Ontvanger), 2015

Prijs: ERCAdvancedWetenschappelijk

symbiosis
organelles
cells
synthetic biology
uptake mechanisms

Checkpoint NANO

Willem Mulder (Ontvanger), nov 2018

Prijs: ERCConsolidatorWetenschappelijk

Precision Medicine
Immune System
Research
Pharmaceutical Preparations
Immunotherapy

Research Center for Functional Molecular Systems

Bert Meijer (Ontvanger), Jan van Hest (Ontvanger), Luc Brunsveld (Ontvanger), Rene Janssen (Ontvanger) & Rint Sijbesma (Ontvanger), 2013

Prijs: NWOZwaartekrachtWetenschappelijk

Netherlands
selection procedure
Ministry of Education
funding
organization

Activiteiten 2015 2015

Dutch Peptide Symposium - 2015

Pascal Welzen (Organisator)
27 mei 2015

Activiteit: Types deelname aan of organisatie van een evenementCongresWetenschappelijk

Scripties/masterproeven

Development of Fischer Tropsch foam catalyst and reactor development: diffusion limitations for FTS foam catalyst

Auteur: van der Linden, C., 1 sep 2017

Begeleider: de Martino, M. (Afstudeerdocent 1)

Scriptie/masterproef: Master

Bestand

Development of reduction responsive polymersomes for controlled drug delivery

Auteur: Stam, R., 13 nov 2018

Begeleider: Pijpers, I. (Afstudeerdocent 1), van Hest, J. (Afstudeerdocent 2), Brunsveld, L. (Afstudeerdocent 2) & Abdelmohsen, L. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Measuring all three vitamin D metabolites on the LC-MS/MS: effects of vitamin D supplementation in pre-dialysis patients

Auteur: Verbon, I., 27 nov 2017

Begeleider: van Dongen, J. (Afstudeerdocent 1) & Schmitz, E. (Afstudeerdocent 2)

Scriptie/masterproef: Master