This study extends a previous 1D agent-based model for Notch signaling in arteries to a 2D formulation. This allows investigation of the effects of cell connectivity on the dynamics of arterial Notch signaling and VSMC phenotypes. Notch signaling for VSMCs with 2-6 neighbouring cells was analyzed. Computational results of the 1D and 2D formulations were also compared.
Ristori, T. (Ontwerper), Stassen, O. M. J. A. (Ontwerper), Sahlgren, C. M. (Ontwerper), Loerakker, S. (Ontwerper) (20 okt. 2020). Data underlying the publication: "Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls". 4TU.Centre for Research Data. 10.4121/12854297