URL study guide
https://tue.osiris-student.nl/onderwijscatalogus/extern/cursus?cursuscode=8BM050&collegejaar=2025&taal=enOmschrijving
This course will discuss principles of human metabolism and its regulation. Basic principles will be discussed first, such as the central human energy metabolism and regulation of metabolism at a cellular level. Then the functional anatomy of digestive tract, metabolism and its regulatory organs are discussed, additionally discussing regulatory hormones. Finally, the knowledge will be integrated into the discussion of whole-body metabolism, and its adaptation to factors such as stress, exercise and disease. The biological theory will be complemented by an engineering perspective on metabolic regulation, by discussion of techniques to statically and dynamically model components of this regulatory system. We will discuss the basics of mathematical graph theory and use these to move from static models to dynamic models of biochemical processes and signalling networks. During the practical part of the course, students will be working with these models and using Python to perform simulations and analyses.Doelstellingen
At the end of this course, the student is able to:1. Describe the molecular details of the conversion of the body's main energy sources (carbohydrates, lipids, proteins) into energy.
2. Understand and describe the compartmentalisation and adaptation of metabolic processes at a cellular level.
3. Understand and describe the functional anatomy of the digestive system for carbohydrates, lipids and proteins.
4. Describe the function of the liver, adipose tissue, and other metabolic tissues in retaining homeostasis through hormonal and neural regulation
5. Describe energy homeostasis in daily life and how it changes due to stress, exercise, and disease
6. Apply concepts of graph theory (connectivity, directionality, cycles, and self-loops) to study metabolic processes and regulation
7. Construct a linear dynamic model of biochemical processes using the law of mass action
8. Explain the function of different terms in a simple system of (possibly nonlinear) ordinary differential equations.
9. Calculate the steady-state conditions for a simple system of ordinary differential equations.
10. Use Python to simulate and analyse systems of ordinary differential equations