Cardiac function

URL study guide

https://tue.osiris-student.nl/onderwijscatalogus/extern/cursus?cursuscode=8VM20&collegejaar=2025&taal=en

Omschrijving

Cardiac pump function is the result of the interaction between the heart and the vascular system. Cardiac properties involved are geometry, orientation of the myofibers in the cardiac wall, mechanical and electrical tissue properties, and coronary perfusion. Relevant vascular properties are valve function, and vascular compliance and resistance. To fulfill the changing oxygen demand of the body, cardiac and vascular properties are time dependent, both on the short term, through regulation, and on the long term, through growth and remodeling.

In this course cardiac pump function is analysed through mathematical models of the underlying properties and processes. These models provide insight into the basis of normal pump function, in the way in which pathological changes in heart and vessels affect cardiac pump function, and in the adaptive response of the heart to these changes. They also provide insight in the way in which clinically observable indicators of decreased pump function can be translated into the underlying pathology at tissue level, which opens up the path to model assisted decision making in the clinic.

Doelstellingen

1. Understanding of the relation between hemodynamics and cardiovascular properties
2. Understanding of the origin and propagation of the action potential, and the ECG
3. Understanding of the mechanical properties of passive and active cardiac tissue
4. Understanding of the relation between cardiac structure and cardiac deformation
5. Understanding of the changes in cardiac deformation in case of infarction or conduction disorders
6. Understanding of cardiac regulation, growth and remodeling
7. Insight in the role of models of heart and circulation in the clinic
 

Beoordelingsmethode

Written examination