The manufacturing industry is undergoing a paradigm shift. Because of increasing connectivity, we can gather a lot of data from manufacturing systems for the first time in history. The increasing connectivity also enables the linking, analysis, and performance optimization of supply chain components, even if they are geographically dispersed. The AI-enabled Manufacturing and Maintenance Lab (AIMM) aims to accelerate developments in this field using Artificial Intelligence. In this interview with Geert-Jan van Houtum, we will take a surface dive into some complex challenges in predictive maintenance.