Systems Medicine of Metabolic Syndrome and its comorbidities

van Riel, N. (Spreker)

Activiteit: Types gesprekken of presentatiesAangemelde presentatieWetenschappelijk


Metabolic Syndrome (MetSyn) is a cluster of metabolic abnormalities: hypertension, obesity, insulin resistance, and dyslipidemia (increased plasma triglyceride and (V)LDL-cholesterol levels, and decreased HDL cholesterol). Common comorbidities include cardiovascular diseases, liver steatosis and type 2 diabetes. The current pharmacological strategies are inadequate to deal with the growing rate of metabolic disorders, and lifestyle modulation including diet adjustment remains the fundamental approach to combat MetSyn. In several projects systems medicine approaches are used to make diagnosis more precise and contribute to the development of novel and personalized treatments. Underlying disease mechanisms are complex and partly unknown. This impacts the development of predictive computational models. Approaches to quantify variability and uncertainty in multi-level systems medicine models will be addressed. Recent findings will be discussed, focusing on the contribution of computational modelling in understanding the metabolic effects of bariatric surgery and pharmacological activation of the Liver X Receptor (LXR).
Periode9 mrt 2016
EvenementstitelBME colloquium: null
LocatieEindhoven, Nederland