BeschrijvingMetabolic Syndrome (MetSyn) is characterized by obesity in combination with several metabolic derangements. MetSyn is a risk factor for cardiovascular diseases, non-alcoholic fatty liver disease and type 2 diabetes. The Systems Medicine project RESOLVE studies the molecular pathology of two hallmarks of MetSyn: hypertriglyceridemia and low HDL-cholesterol. Bariatric surgery is currently the most effective treatment of morbid obesity, but also of the co-morbidities associated with MetSyn. The metabolic benefits of bariatric surgery reach further than the long term reduction in body weight by reduced food intake. In Roux-en-Y gastric bypass the rewiring of the intestinal track impacts digestion, absorption and metabolism. Through combining basic pre-clinical and clinical research, network analysis and computational modelling, we try to unravel the underlying dynamics and mechanisms. Changes in gut hormone dynamics, microbiota composition and bile acids composition and dynamics have been observed. Here we report on the role of bile acids as contributors to the health benefits associated with metabolic surgery.
|Periode||27 okt 2016|
|Evenementstitel||EASyM: First conference of the European Association of Systems Medicine|