Whole brain 31P MRSI at 7T with a dual-tuned receive array

Benjamin C. Rowland, Ian D. Driver, Mohamed Tachrount, Dennis W.J. Klomp, Debra Rivera, Ria Forner, Anh Pham, Michel Italiaander, Richard G. Wise

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)


PURPOSE: The design and performance of a novel head coil setup for 31 P spectroscopy at ultra-high field strengths (7T) is presented. The described system supports measurements at both the 1 H and 31 P resonance frequencies.

METHODS: The novel coil consists of 2, actively detunable, coaxial birdcage coils to give homogeneous transmit, combined with a double resonant 30 channel receive array. This allows for anatomical imaging combined with 31 P acquisitions over the whole head, without changing coils or disturbing the subject. A phosphate buffer phantom and 3 healthy volunteers were scanned with a pulse acquire CSI sequence using both the novel array coil and a conventional transceiver birdcage. Four different methods of combining the array channels were compared at 3 different levels of SNR.

RESULTS: The novel coil setup delivers significantly increased 31 P SNR in the peripheral regions of the brain, reaching up to factor 8, while maintaining comparable performance relative to the birdcage in the center.

CONCLUSIONS: The new system offers the potential to acquire whole brain 31 P MRSI with superior signal relative to the standard options.

Original languageEnglish
Pages (from-to)765-775
Number of pages11
JournalMagnetic Resonance in Medicine
Issue number2
Publication statusPublished - 1 Feb 2020


We gratefully acknowledge the assistance of Alison Paul and Craig James in the preparation of phantoms. RGW thanks the Higher Education Funding Council for Wales. We acknowledge the generous support of the UK Medical Research Council (MR/M008932/1), the Welsh Government and Cardiff University for the CUBRIC ultra-high field imaging facility and associated researchers (BCR). We would like to thank Wellcome for supporting this work: Wellcome Strategic Award, ?Multi-scale and multi-modal assessment of coupling in the healthy and diseased brain?, grant reference 104943/ Z/14/Z (RGW and MT).

FundersFunder number
Wellcome Trust104943/ Z/14/Z
Horizon 2020 Framework Programme801075
Llywodraeth Cymru
Medical Research CouncilMR/M008932/1
Higher Education Funding Council for Wales
Cardiff University


    • 31P
    • dual-tuned
    • MRSI
    • phosphorus
    • receive array
    • spectroscopy
    • Protons
    • Magnetic Resonance Spectroscopy
    • Humans
    • Signal-To-Noise Ratio
    • Healthy Volunteers
    • Equipment Design
    • Brain/diagnostic imaging
    • Magnetic Resonance Imaging
    • Head/diagnostic imaging
    • Phosphorus/chemistry
    • Image Processing, Computer-Assisted/methods
    • Phantoms, Imaging


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