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Ways and Methods for Controlling Biomolecular Structures Using Magnetic Nanoparticles Activated by an Alternating Magnetic Field

  • Yu I. Golovin
  • , A.O. Zhigachev
  • , M.V. Efremova
  • , A.G. Majouga
  • , A.V. Kabanov
  • , N.L. Klyachko

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Functionalized magnetic nanoparticles (MNPs) controlled by an external magnetic field provide a new generation of promising nanobiomedical platform. Due to their ability to locally change the state of a biochemical system through two physical processes—thermal and nanomagnetomechanical—they are already used in experiments on targeted drug delivery and therapy of oncological diseases. This work considers the peculiarities, advantages, and drawbacks of each of these processes and the main parameters of the magnetic field controlling the MNP effect on different biomolecular targets. A brief review and comparative analysis of main experimental studies carried out in the scope of magnetic hyperthermia and nanomagnetomechanical actuation are carried out.

Original languageEnglish
Pages (from-to)295-304
Number of pages10
JournalNanotechnologies in Russia
Volume13
Issue number5-6
DOIs
Publication statusPublished - 1 May 2018
Externally publishedYes

Funding

ACKNOWLEDGMENTS This work was supported by the Russian Science Foundation (project no. 14-13-00731) and the Russian Foundation for Basic Research (project nos. 17-54-33027, 17-42-680803).

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