Amphiphilic block copolymers in soln. can assembly into a wide range of colloidal materials, which have been widely investigated as drug delivery vehicles and catalytic nanoreactors. Due to their kinetically trapped nature, self-assembly is often performed using the solvent switch protocol. While numerous exptl. and theor. investigations into the mechanism of self-assembly have been conducted in an effort to gain more control over this process, there has never been a real-time, real space investigation of the assembly process on the nanoscale. Here we present the first observation of block copolymer assembly via the solvent switch process using liq. phase transmission electron microscopy. We show the formation of polymer vesicles, cylindrical micelles and multicompartmental structures and discuss the different mechanisms of self-assembly with supporting data from ex-situ cryoTEM measurements and SCF (SCF) lattice computations.
|Title of host publication||Abstracts of Papers, 255th ACS National Meeting & Exposition|
|Publisher||American Chemical Society|
|Publication status||Published - 18 Mar 2018|
255th ACS National Meeting - New Orleans Convention Center, New Orleans, United States
Duration: 18 Mar 2018 → 22 Mar 2018
255th ACS National Meeting
|Period||18/03/18 → 22/03/18|