TY - JOUR
T1 - Voxel size dependency, reproducibility and sensitivity of an in vivo bone loading estimation algorithm
AU - Christen, P.
AU - Schulte, F.A.
AU - Zwahlen, A.
AU - van Rietbergen, B.
AU - Boutroy, S.
AU - Melton, L.J.
AU - Amin, S.
AU - Khosla, S.
AU - Goldhahn, J.
AU - Müller, R.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - A bone loading estimation algorithm was previously developed that provides in vivo loading conditions required for in vivo bone remodelling simulations. The algorithm derives a bone's loading history from its microstructure as assessed by high-resolution (HR) computed tomography (CT). This reverse engineering approach showed accurate and realistic results based on micro-CT and HR-peripheral quantitative CT images. However, its voxel size dependency, reproducibility and sensitivity still need to be investigated, which is the purpose of this study. Voxel size dependency was tested on cadaveric distal radii with micro-CT images scanned at 25 mm and downscaled to 50, 61, 75, 82, 100, 125 and 150 mm. Reproducibility was calculated with repeated in vitro as well as in vivo HR-pQCT measurements at 82 mm. Sensitivity was defined using HR-pQCT images from women with fracture versus non-fracture, and low versus high bone volume fraction, expecting similar and different loading histories, respectively. Our results indicate that the algorithm is voxel size independent within an average (maximum) error of 8.2% (32.9%) at 61 mm, but that the dependency increases considerably at voxel sizes bigger than 82 mm. In vitro and in vivo reproducibility are up to 4.5% and 10.2%, respectively, which is comparable to other in vitro studies and slightly higher than in other in vivo studies. Subjects with different bone volume fraction were clearly distinguished but not subjects with and without fracture. This is in agreement with bone adapting to customary loading but not to fall loads. We conclude that the in vivo bone loading estimation algorithm provides reproducible, sensitive and fairly voxel size independent results at up to 82 mm, but that smaller voxel sizes would be advantageous.
AB - A bone loading estimation algorithm was previously developed that provides in vivo loading conditions required for in vivo bone remodelling simulations. The algorithm derives a bone's loading history from its microstructure as assessed by high-resolution (HR) computed tomography (CT). This reverse engineering approach showed accurate and realistic results based on micro-CT and HR-peripheral quantitative CT images. However, its voxel size dependency, reproducibility and sensitivity still need to be investigated, which is the purpose of this study. Voxel size dependency was tested on cadaveric distal radii with micro-CT images scanned at 25 mm and downscaled to 50, 61, 75, 82, 100, 125 and 150 mm. Reproducibility was calculated with repeated in vitro as well as in vivo HR-pQCT measurements at 82 mm. Sensitivity was defined using HR-pQCT images from women with fracture versus non-fracture, and low versus high bone volume fraction, expecting similar and different loading histories, respectively. Our results indicate that the algorithm is voxel size independent within an average (maximum) error of 8.2% (32.9%) at 61 mm, but that the dependency increases considerably at voxel sizes bigger than 82 mm. In vitro and in vivo reproducibility are up to 4.5% and 10.2%, respectively, which is comparable to other in vitro studies and slightly higher than in other in vivo studies. Subjects with different bone volume fraction were clearly distinguished but not subjects with and without fracture. This is in agreement with bone adapting to customary loading but not to fall loads. We conclude that the in vivo bone loading estimation algorithm provides reproducible, sensitive and fairly voxel size independent results at up to 82 mm, but that smaller voxel sizes would be advantageous.
KW - Bone loading estimation
KW - HR-pQCT
KW - Human distal radius
KW - Reproducibility
KW - Sensitivity
KW - Voxel size dependency
UR - http://www.scopus.com/inward/record.url?scp=84958605926&partnerID=8YFLogxK
U2 - 10.1098/rsif.2015.0991
DO - 10.1098/rsif.2015.0991
M3 - Article
C2 - 26790999
AN - SCOPUS:84958605926
SN - 1742-5689
VL - 13
JO - Journal of the Royal Society Interface
JF - Journal of the Royal Society Interface
IS - 114
M1 - 20150991
ER -