Visual analytics in histopathology diagnostics: a protocol-based approach

A. Corvo, M.A. Westenberg, Marc A. van Driel, J.J. van Wijk

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)
102 Downloads (Pure)


Computer-Aided-Diagnosis (CAD) systems supporting the diagnostic process are widespread in radiology. Digital Pathology is still behind in the introduction of such solutions. Several studies investigated pathologists' behavior but only a few aimed to improve the diagnostic and report process with novel applications. In this work we designed and implemented a first protocol-based CAD viewer supported by visual analytics. The system targets the optimization of the diagnostic workflow in breast cancer diagnosis by means of three image analysis features that belong to the standard grading system (Nottingham Histologic Grade). A pathologist's routine was tracked during the examination of breast cancer tissue slides and diagnostic traces were analyzed from a qualitative perspective. Accordingly, a set of generic requirements was elicited to define the design and the implementation of the CAD-Viewer. A first qualitative evaluation conducted with five pathologists shows that the interface suffices the diagnostic workflow and diminishes the manual effort. We present promising evidence of the usefulness of our CAD-viewer and opportunities for its extension and integration in clinical practice. As a conclusion, the findings demonstrate that it is feasibile to optimize the Nottingham Grading workflow and, generally, the histological diagnosis by integrating computational pathology data with visual analytics techniques.
Original languageEnglish
Title of host publicationVCBM 2018 - Eurographics Workshop on Visual Computing for Biology and Medicine
EditorsAnna Puig, Thomas Schultz, Anna Vilanova, Ingrid Hotz, Barbora Kozlikova, Pere-Pau Vazquez
PublisherEurographics Association
Number of pages10
ISBN (Electronic)9783038680567
ISBN (Print)978-3-03868-056-7
Publication statusPublished - 2018
Event2018 Eurographics Workshop on Visual Computing for Biology and Medicine, VCBM 2018 - Granada, Spain
Duration: 20 Sep 201821 Sep 2018
Conference number: 8


Conference2018 Eurographics Workshop on Visual Computing for Biology and Medicine, VCBM 2018
Abbreviated titleVCBM 2018
Internet address


  • Visual Analytics
  • Breast Cancer
  • Digital Pathology
  • Computational Pathology


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