Visual analytics in histopathology diagnostics: a protocol-based approach

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Abstract

Computer-Aided-Diagnosis (CAD) systems supporting the diagnostic process are widespread in radiology. Digital Pathology is still behind in the introduction of such solutions. Several studies investigated pathologists' behavior but only a few aimed to improve the diagnostic and report process with novel applications. In this work we designed and implemented a first protocol-based CAD viewer supported by visual analytics. The system targets the optimization of the diagnostic workflow in breast cancer diagnosis by means of three image analysis features that belong to the standard grading system (Nottingham Histologic Grade). A pathologist's routine was tracked during the examination of breast cancer tissue slides and diagnostic traces were analyzed from a qualitative perspective. Accordingly, a set of generic requirements was elicited to define the design and the implementation of the CAD-Viewer. A first qualitative evaluation conducted with five pathologists shows that the interface suffices the diagnostic workflow and diminishes the manual effort. We present promising evidence of the usefulness of our CAD-viewer and opportunities for its extension and integration in clinical practice. As a conclusion, the findings demonstrate that it is feasibile to optimize the Nottingham Grading workflow and, generally, the histological diagnosis by integrating computational pathology data with visual analytics techniques.
Original languageEnglish
Title of host publicationEurographics Workshop on Visual Computing for Biology and Medicine
PublisherEurographics Association
ISBN (Print)978-3-03868-056-7
DOIs
Publication statusPublished - 2018
Event2018 Eurographics Workshop on Visual Computing for Biology and Medicine - Granada, Spain
Duration: 20 Sep 201821 Sep 2018
Conference number: 8
https://lsi.ugr.es/vcbm2018/

Conference

Conference2018 Eurographics Workshop on Visual Computing for Biology and Medicine
Abbreviated titleVCBM
CountrySpain
CityGranada
Period20/09/1821/09/18
Internet address

Fingerprint

Computer aided diagnosis
Pathology
Radiology
Image analysis
Tissue

Keywords

  • Visual Analytics
  • Breast Cancer
  • Digital Pathology
  • Computational Pathology

Cite this

Corvo, A., Westenberg, M. A., van Driel, M. A., & van Wijk, J. J. (2018). Visual analytics in histopathology diagnostics: a protocol-based approach. In Eurographics Workshop on Visual Computing for Biology and Medicine Eurographics Association. https://doi.org/10.2312/vcbm.20181226
Corvo, A. ; Westenberg, M.A. ; van Driel, Marc A. ; van Wijk, J.J. / Visual analytics in histopathology diagnostics: a protocol-based approach. Eurographics Workshop on Visual Computing for Biology and Medicine. Eurographics Association, 2018.
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Corvo, A, Westenberg, MA, van Driel, MA & van Wijk, JJ 2018, Visual analytics in histopathology diagnostics: a protocol-based approach. in Eurographics Workshop on Visual Computing for Biology and Medicine. Eurographics Association, 2018 Eurographics Workshop on Visual Computing for Biology and Medicine, Granada, Spain, 20/09/18. https://doi.org/10.2312/vcbm.20181226

Visual analytics in histopathology diagnostics: a protocol-based approach. / Corvo, A.; Westenberg, M.A.; van Driel, Marc A.; van Wijk, J.J.

Eurographics Workshop on Visual Computing for Biology and Medicine. Eurographics Association, 2018.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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Corvo A, Westenberg MA, van Driel MA, van Wijk JJ. Visual analytics in histopathology diagnostics: a protocol-based approach. In Eurographics Workshop on Visual Computing for Biology and Medicine. Eurographics Association. 2018 https://doi.org/10.2312/vcbm.20181226