Visual activation patterns in patients with optic neuritis: an fMRI pilot study

S.A.R.B. Rombouts; R.H.C. Lazeron; P. Scheltens; B.M.J. Uitdehaag; M. Sprenger; J. Valk; F. Barkhof

Visual activation patterns in patients with optic neuritis: an fMRI pilot study

S.A.R.B. Rombouts, R.H.C. Lazeron, P. Scheltens, B.M.J. Uitdehaag, M. Sprenger, J. Valk, F. Barkhof

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We studied the use of functional MRI (fMRI) with visual stimulation in nine patients with unilateral optic neuritis. Eight healthy subjects served as controls. Patients showed reduced activation upon stimulation of the affected eye, on average 33% (range 0 to 156%) of the average monocular activation in the control group. Decreased activation was also seen for the unaffected eye (61% of control values, range 3 to 133%). We conclude that fMRI with visual stimulation is feasible in patients with optic neuritis and deserves future study.

Original language	English
Pages (from-to)	1896-1899
Number of pages	4
Journal	Neurology
Volume	50
Issue number	6
Publication status	Published - Jun 1998
Externally published	Yes

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title = "Visual activation patterns in patients with optic neuritis: an fMRI pilot study",

abstract = "We studied the use of functional MRI (fMRI) with visual stimulation in nine patients with unilateral optic neuritis. Eight healthy subjects served as controls. Patients showed reduced activation upon stimulation of the affected eye, on average 33% (range 0 to 156%) of the average monocular activation in the control group. Decreased activation was also seen for the unaffected eye (61% of control values, range 3 to 133%). We conclude that fMRI with visual stimulation is feasible in patients with optic neuritis and deserves future study.",

author = "S.A.R.B. Rombouts and R.H.C. Lazeron and P. Scheltens and B.M.J. Uitdehaag and M. Sprenger and J. Valk and F. Barkhof",

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AU - Rombouts, S.A.R.B.

AU - Lazeron, R.H.C.

AU - Scheltens, P.

AU - Uitdehaag, B.M.J.

AU - Sprenger, M.

AU - Valk, J.

AU - Barkhof, F.

PY - 1998/6

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N2 - We studied the use of functional MRI (fMRI) with visual stimulation in nine patients with unilateral optic neuritis. Eight healthy subjects served as controls. Patients showed reduced activation upon stimulation of the affected eye, on average 33% (range 0 to 156%) of the average monocular activation in the control group. Decreased activation was also seen for the unaffected eye (61% of control values, range 3 to 133%). We conclude that fMRI with visual stimulation is feasible in patients with optic neuritis and deserves future study.

AB - We studied the use of functional MRI (fMRI) with visual stimulation in nine patients with unilateral optic neuritis. Eight healthy subjects served as controls. Patients showed reduced activation upon stimulation of the affected eye, on average 33% (range 0 to 156%) of the average monocular activation in the control group. Decreased activation was also seen for the unaffected eye (61% of control values, range 3 to 133%). We conclude that fMRI with visual stimulation is feasible in patients with optic neuritis and deserves future study.

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