Visible-light-promoted iron-catalyzed C(sp2)–C(sp3) Kumada cross-coupling in flow

Xiao Jing Wei, Irini Abdiaj, Carlo Sambiagio, Chenfei Li, Eli Zysman-Colman, Jesús Alcázar, Timothy Noël (Corresponding author)

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7 Citations (Scopus)
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Abstract

A continuous-flow, visible-light-promoted method has been developed to overcome the limitations of iron-catalyzed Kumada–Corriu cross-coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes’ residence time, considerably enhancing the applicability of this iron-catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application.

Original languageEnglish
Pages (from-to)13030-13034
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number37
DOIs
Publication statusPublished - 9 Sep 2019

Keywords

  • cross-coupling
  • flow chemistry
  • iron catalysis
  • Kumada coupling
  • photocatalysis

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