Visible-light photocatalytic difluoroalkylation-induced 1, 2-heteroarene migration of allylic alcohols in batch and flow

X. Wei; T. Noël

doi:10.1021/acs.joc.8b01624

Visible-light photocatalytic difluoroalkylation-induced 1, 2-heteroarene migration of allylic alcohols in batch and flow

X. Wei
, T. Noël

Research output: Contribution to journal › Article › Academic › peer-review

46 Citations (Scopus)

151 Downloads (Pure)

Abstract

A convenient method for the preparation of sp3-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols. Here we describe for the first time the benefits of using flow to facilitate such migration reactions, including shorter reaction times, higher selectivities, and opportunities to scale the chemistry.

Original language	English
Pages (from-to)	11377–11384
Number of pages	8
Journal	Journal of Organic Chemistry
Volume	83
Issue number	18
DOIs	https://doi.org/10.1021/acs.joc.8b01624
Publication status	Published - 21 Sept 2018

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title = "Visible-light photocatalytic difluoroalkylation-induced 1, 2-heteroarene migration of allylic alcohols in batch and flow",

abstract = "A convenient method for the preparation of sp3-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols. Here we describe for the first time the benefits of using flow to facilitate such migration reactions, including shorter reaction times, higher selectivities, and opportunities to scale the chemistry.",

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year = "2018",

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T1 - Visible-light photocatalytic difluoroalkylation-induced 1, 2-heteroarene migration of allylic alcohols in batch and flow

AU - Wei, X.

AU - Noël, T.

PY - 2018/9/21

Y1 - 2018/9/21

N2 - A convenient method for the preparation of sp3-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols. Here we describe for the first time the benefits of using flow to facilitate such migration reactions, including shorter reaction times, higher selectivities, and opportunities to scale the chemistry.

AB - A convenient method for the preparation of sp3-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols. Here we describe for the first time the benefits of using flow to facilitate such migration reactions, including shorter reaction times, higher selectivities, and opportunities to scale the chemistry.

UR - https://www.scopus.com/pages/publications/85050361125

U2 - 10.1021/acs.joc.8b01624

DO - 10.1021/acs.joc.8b01624

M3 - Article

C2 - 30020781

SN - 0022-3263

VL - 83

SP - 11377

EP - 11384

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 18

ER -

Visible-light photocatalytic difluoroalkylation-induced 1, 2-heteroarene migration of allylic alcohols in batch and flow

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