Virus-like particles as crosslinkers in fibrous biomimetic hydrogels: Approaches towards capsid rupture and gel repair

Daniël C. Schoenmakers, Lise Schoonen, Martin G.T.A. Rutten, Roeland J.M. Nolte, Alan E. Rowan, Jan C.M. van Hest, Paul H.J. Kouwer

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Abstract

Biological hydrogels can become many times stiffer under deformation. This unique ability has only recently been realised in fully synthetic gels. Typically, these networks are composed of semi-flexible polymers and bundles and show such large mechanical responses at very small strains, which makes them particularly suitable for application as strain-responsive materials. In this work, we introduced strain-responsiveness by crosslinking the architecture with a multi-functional virus-like particle. At high stresses, we find that the virus particles disintegrate, which creates an (irreversible) mechanical energy dissipation pathway, analogous to the high stress response of fibrin networks. A cooling-heating cycle allows for re-crosslinking at the damaged site, which gives rise to much stronger hydrogels. Virus particles and capsids are promising drug delivery vehicles and our approach offers an effective strategy to trigger the release mechanically without compromising the mechanical integrity of the host material.

Original languageEnglish
Pages (from-to)1442-1448
Number of pages7
JournalSoft Matter
Volume14
Issue number8
DOIs
Publication statusPublished - 1 Jan 2018

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Hydrogels
biomimetics
Biomimetics
viruses
Viruses
Repair
Gels
gels
crosslinking
Crosslinking
fibrin
Fibrin
Drug delivery
integrity
bundles
Energy dissipation
delivery
Polymers
vehicles
drugs

Cite this

Schoenmakers, D. C., Schoonen, L., Rutten, M. G. T. A., Nolte, R. J. M., Rowan, A. E., van Hest, J. C. M., & Kouwer, P. H. J. (2018). Virus-like particles as crosslinkers in fibrous biomimetic hydrogels: Approaches towards capsid rupture and gel repair. Soft Matter, 14(8), 1442-1448. https://doi.org/10.1039/c7sm02320k
Schoenmakers, Daniël C. ; Schoonen, Lise ; Rutten, Martin G.T.A. ; Nolte, Roeland J.M. ; Rowan, Alan E. ; van Hest, Jan C.M. ; Kouwer, Paul H.J. / Virus-like particles as crosslinkers in fibrous biomimetic hydrogels : Approaches towards capsid rupture and gel repair. In: Soft Matter. 2018 ; Vol. 14, No. 8. pp. 1442-1448.
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Schoenmakers, DC, Schoonen, L, Rutten, MGTA, Nolte, RJM, Rowan, AE, van Hest, JCM & Kouwer, PHJ 2018, 'Virus-like particles as crosslinkers in fibrous biomimetic hydrogels: Approaches towards capsid rupture and gel repair', Soft Matter, vol. 14, no. 8, pp. 1442-1448. https://doi.org/10.1039/c7sm02320k

Virus-like particles as crosslinkers in fibrous biomimetic hydrogels : Approaches towards capsid rupture and gel repair. / Schoenmakers, Daniël C.; Schoonen, Lise; Rutten, Martin G.T.A.; Nolte, Roeland J.M.; Rowan, Alan E.; van Hest, Jan C.M.; Kouwer, Paul H.J.

In: Soft Matter, Vol. 14, No. 8, 01.01.2018, p. 1442-1448.

Research output: Contribution to journalArticleAcademicpeer-review

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