Virtual screening and experimental validation reveal novel small-molecule inhibitores of 14-3-3 protein-protein interactions

P. Thiel, L. Röglin, N. Meissner, S. Henning, O. Kohlbacher, C. Ottmann

Research output: Contribution to journalArticleAcademicpeer-review

38 Citations (Scopus)
2 Downloads (Pure)

Abstract

We report first non-covalent and exclusively extracellular inhibitors of 14-3-3 protein-protein interactions identified by virtual screening. Optimization by crystal structure analysis and in vitro binding assays yielded compounds capable of disrupting the interaction of 14-3-3s with aminopeptidase N in a cellular assay.
Original languageEnglish
Pages (from-to)8468-8470
Number of pages2
JournalChemical Communications, ChemComm
Volume49
Issue number76
DOIs
Publication statusPublished - 2013

Fingerprint

Dive into the research topics of 'Virtual screening and experimental validation reveal novel small-molecule inhibitores of 14-3-3 protein-protein interactions'. Together they form a unique fingerprint.

Cite this