Versatile microfluidic flow generated by moulded magnetic artificial cilia

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
98 Downloads (Pure)

Abstract

Magnetic artificial cilia (MAC) are flexible hair-like micro-actuators inspired by biological cilia. When integrated in a microfluidic device and actuated by an external (electro-)magnet, MAC can generate fluid flows. Our MAC are made of a composite material of polydimethylsiloxane (PDMS) and magnetic microparticles (Carbonyl iron powder). In this paper, we demonstrate a fabrication process based on micro-moulding to manufacture MAC, in which we can vary the magnetic particle distribution within the cilia from (1) a random distribution, to (2) a linearly aligned distribution to (3) a concentrated distribution in the tips of the cilia. Magnetization measurements show that the aligned distribution leads to a substantial increase of magnetic susceptibility, which dramatically enhances their response to an applied magnetic field. When integrated in a microfluidic channel, the improved MAC can induce versatile flows, for example (i) circulatory fluid flows with flow speeds up to 250 μm/s which is substantially above the performance of most of the previously developed artificial cilia, (ii) direction-reversible flows, (iii) oscillating flows, and (iv) pulsatile flows, by changing the magnetic actuation mode. Compared to other pumping methods, this on-chip/in-situ micro-pump requires no tubing or electric connections, reducing the usage of reagents by minimizing “dead volumes” avoiding undesirable electrical effects, and accommodating a wide range of different fluids. These results demonstrate that our MAC can be used as versatile integrated micropump in microfluidic devices, with great potential for future lab-on-a-chip applications.

Original languageEnglish
Pages (from-to)614-624
Number of pages11
JournalSensors and Actuators, B: Chemical
Volume263
DOIs
Publication statusPublished - 15 Jun 2018

Fingerprint

Microfluidics
Flow of fluids
microfluidic devices
Oscillating flow
fluid flow
Pulsatile flow
Lab-on-a-chip
Iron powder
chips
Polydimethylsiloxane
oscillating flow
Tubing
Magnetic susceptibility
Molding
Magnets
Magnetization
hair
microparticles
Actuators
statistical distributions

Keywords

  • Lab-on-Chip
  • Magnetic artificial cilia
  • Magnetic particle distribution
  • Micro-moulding
  • Micro-pump
  • Versatile microfluidic flow

Cite this

@article{0c4efea418824bf482c94db26c8ea641,
title = "Versatile microfluidic flow generated by moulded magnetic artificial cilia",
abstract = "Magnetic artificial cilia (MAC) are flexible hair-like micro-actuators inspired by biological cilia. When integrated in a microfluidic device and actuated by an external (electro-)magnet, MAC can generate fluid flows. Our MAC are made of a composite material of polydimethylsiloxane (PDMS) and magnetic microparticles (Carbonyl iron powder). In this paper, we demonstrate a fabrication process based on micro-moulding to manufacture MAC, in which we can vary the magnetic particle distribution within the cilia from (1) a random distribution, to (2) a linearly aligned distribution to (3) a concentrated distribution in the tips of the cilia. Magnetization measurements show that the aligned distribution leads to a substantial increase of magnetic susceptibility, which dramatically enhances their response to an applied magnetic field. When integrated in a microfluidic channel, the improved MAC can induce versatile flows, for example (i) circulatory fluid flows with flow speeds up to 250 μm/s which is substantially above the performance of most of the previously developed artificial cilia, (ii) direction-reversible flows, (iii) oscillating flows, and (iv) pulsatile flows, by changing the magnetic actuation mode. Compared to other pumping methods, this on-chip/in-situ micro-pump requires no tubing or electric connections, reducing the usage of reagents by minimizing “dead volumes” avoiding undesirable electrical effects, and accommodating a wide range of different fluids. These results demonstrate that our MAC can be used as versatile integrated micropump in microfluidic devices, with great potential for future lab-on-a-chip applications.",
keywords = "Lab-on-Chip, Magnetic artificial cilia, Magnetic particle distribution, Micro-moulding, Micro-pump, Versatile microfluidic flow",
author = "Shuaizhong Zhang and Ye Wang and Reinoud Lavrijsen and Onck, {Patrick R.} and {den Toonder}, J.M.J.",
year = "2018",
month = "6",
day = "15",
doi = "10.1016/j.snb.2018.01.189",
language = "English",
volume = "263",
pages = "614--624",
journal = "Sensors and Actuators, B: Chemical",
issn = "0925-4005",
publisher = "Elsevier",

}

Versatile microfluidic flow generated by moulded magnetic artificial cilia. / Zhang, Shuaizhong; Wang, Ye; Lavrijsen, Reinoud; Onck, Patrick R.; den Toonder, J.M.J.

In: Sensors and Actuators, B: Chemical, Vol. 263, 15.06.2018, p. 614-624.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Versatile microfluidic flow generated by moulded magnetic artificial cilia

AU - Zhang, Shuaizhong

AU - Wang, Ye

AU - Lavrijsen, Reinoud

AU - Onck, Patrick R.

AU - den Toonder, J.M.J.

PY - 2018/6/15

Y1 - 2018/6/15

N2 - Magnetic artificial cilia (MAC) are flexible hair-like micro-actuators inspired by biological cilia. When integrated in a microfluidic device and actuated by an external (electro-)magnet, MAC can generate fluid flows. Our MAC are made of a composite material of polydimethylsiloxane (PDMS) and magnetic microparticles (Carbonyl iron powder). In this paper, we demonstrate a fabrication process based on micro-moulding to manufacture MAC, in which we can vary the magnetic particle distribution within the cilia from (1) a random distribution, to (2) a linearly aligned distribution to (3) a concentrated distribution in the tips of the cilia. Magnetization measurements show that the aligned distribution leads to a substantial increase of magnetic susceptibility, which dramatically enhances their response to an applied magnetic field. When integrated in a microfluidic channel, the improved MAC can induce versatile flows, for example (i) circulatory fluid flows with flow speeds up to 250 μm/s which is substantially above the performance of most of the previously developed artificial cilia, (ii) direction-reversible flows, (iii) oscillating flows, and (iv) pulsatile flows, by changing the magnetic actuation mode. Compared to other pumping methods, this on-chip/in-situ micro-pump requires no tubing or electric connections, reducing the usage of reagents by minimizing “dead volumes” avoiding undesirable electrical effects, and accommodating a wide range of different fluids. These results demonstrate that our MAC can be used as versatile integrated micropump in microfluidic devices, with great potential for future lab-on-a-chip applications.

AB - Magnetic artificial cilia (MAC) are flexible hair-like micro-actuators inspired by biological cilia. When integrated in a microfluidic device and actuated by an external (electro-)magnet, MAC can generate fluid flows. Our MAC are made of a composite material of polydimethylsiloxane (PDMS) and magnetic microparticles (Carbonyl iron powder). In this paper, we demonstrate a fabrication process based on micro-moulding to manufacture MAC, in which we can vary the magnetic particle distribution within the cilia from (1) a random distribution, to (2) a linearly aligned distribution to (3) a concentrated distribution in the tips of the cilia. Magnetization measurements show that the aligned distribution leads to a substantial increase of magnetic susceptibility, which dramatically enhances their response to an applied magnetic field. When integrated in a microfluidic channel, the improved MAC can induce versatile flows, for example (i) circulatory fluid flows with flow speeds up to 250 μm/s which is substantially above the performance of most of the previously developed artificial cilia, (ii) direction-reversible flows, (iii) oscillating flows, and (iv) pulsatile flows, by changing the magnetic actuation mode. Compared to other pumping methods, this on-chip/in-situ micro-pump requires no tubing or electric connections, reducing the usage of reagents by minimizing “dead volumes” avoiding undesirable electrical effects, and accommodating a wide range of different fluids. These results demonstrate that our MAC can be used as versatile integrated micropump in microfluidic devices, with great potential for future lab-on-a-chip applications.

KW - Lab-on-Chip

KW - Magnetic artificial cilia

KW - Magnetic particle distribution

KW - Micro-moulding

KW - Micro-pump

KW - Versatile microfluidic flow

UR - http://www.scopus.com/inward/record.url?scp=85042716812&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2018.01.189

DO - 10.1016/j.snb.2018.01.189

M3 - Article

AN - SCOPUS:85042716812

VL - 263

SP - 614

EP - 624

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

SN - 0925-4005

ER -