Vascular mechanobiology: towards control of in situ regeneration

E.E. van Haaften, C.V.C. Bouten, N.A. Kurniawan

Research output: Contribution to journalReview articlepeer-review

41 Citations (Scopus)
233 Downloads (Pure)


The paradigm of regenerative medicine has recently shifted from in vitro to in situ tissue engineering: implanting a cell-free, biodegradable, off-the-shelf available scaffold and inducing the development of functional tissue by utilizing the regenerative potential of the body itself. This approach offers a prospect of not only alleviating the clinical demand for autologous vessels but also circumventing the current challenges with synthetic grafts. In order to move towards a hypothesis-driven engineering approach, we review three crucial aspects that need to be taken into account when regenerating vessels: (1) the structure-function relation for attaining mechanical homeostasis of vascular tissues, (2) the environmental cues governing cell function, and (3) the available experimental platforms to test instructive scaffolds for in situ tissue engineering. The understanding of cellular responses to environmental cues leads to the development of computational models to predict tissue formation and maturation, which are validated using experimental platforms recapitulating the (patho)physiological micro-environment. With the current advances, a progressive shift is anticipated towards a rational and effective approach of building instructive scaffolds for in situ vascular tissue regeneration.

Original languageEnglish
Article number19
Pages (from-to)1-24
Issue number3
Publication statusPublished - Sept 2017


  • Journal Article
  • Review
  • mechanosensing
  • scaffolds
  • in situ tissue engineering
  • regeneration
  • mechanotransduction
  • growth and remodeling
  • vessels
  • tissue homeostasis


Dive into the research topics of 'Vascular mechanobiology: towards control of in situ regeneration'. Together they form a unique fingerprint.

Cite this