Vanishing microwave effects : influence of heterogeneity

M.H.C.L. Dressen, B.H.P. Kruijs, van de, J. Meuldijk, J.A.J.M. Vekemans, L.A. Hulshof

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)

Abstract

A consistent setup of experiments has been conducted to demonstrate an enhanced reaction rate under microwave irradiation as compared to conventional heating, i.e. a real microwave effect. It was found that addition of a cosolvent, diminishing the heterogeneous character of the reaction mixture, greatly reduced the microwave effect. This was demonstrated by two examples; selective mono-urea formation and racemization of an N-acetylamino acid. Furthermore, formation of a Grignard reagent was accelerated under MW irradiation by electrostatic etching of the metal surface. The microwave effect observed in these reactions seems to rely on heterogeneity and specific interactions on the solid–liquid interface. Basic understanding of these findings is crucial for scaling up microwave assisted processes.
Original languageEnglish
Pages (from-to)865-869
JournalOrganic Process Research & Development
Volume11
Issue number3
DOIs
Publication statusPublished - 2007

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