Validation of coronary flow reserve measurements by thermodilution in clinical practice

Emanuele Barbato, Wilbert Aarnoudse, Wim R. Aengevaeren, Gerald Werner, Volker Klauss, Waldemar Bojara, Istvan Herzfeld, Keith G. Oldroyd, Nico H.J. Pijls, Bernard De Bruyne

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136 Citations (Scopus)


Background: Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFR thermo obtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFR Doppler). Methods and results: In 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFRthermo and CFRDoppler were measured. FFR could be obtained in all patients (100%). An optimal CFRDoppler could be obtained in 69% of the patients. CFRthermo could be obtained in 97% of the patients. A significant correlation was found between CFRDoppler and CFR thermo (r=0.79, P<0.0001) but CFRthermo tended to be higher than CFRDoppler. Conclusions: In a setting close to 'real world' practice, this multicentric study confirms the feasibility and reliability of thermodilution-derived CFR. In addition, the safety and the swiftness of assessing FFR and CFR with one single guide wire makes the latter a unique clinical tool for the evaluation of the coronary circulation.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalEuropean Heart Journal
Issue number3
Publication statusPublished - 1 Feb 2004


  • Coronary artery disease
  • Coronary flow reserve
  • Fractional flow reserve
  • Ischaemia
  • Thermodilution


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