Validation of adaptive bone-remodeling simulation models

R. Huiskes

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

13 Citations (Scopus)
109 Downloads (Pure)


Using computer models based on Finite Element Analysis (FEA), Wolffs paradigm of mechanically-controlled adaptive bone remodeling can be simulated. These simulation models use empirical mathematical rules that describe the assumed relationships between local bone loads and bone mass. These models are particularly valuable for preclinical testing of orthopaedic implants, relative to their bone-maintaining capacities. In this chapter the question of validity of these models for these purposes is considered. Furthermore, an overview is presented of validation studies that were performed by the research group of the author.
Original languageEnglish
Title of host publicationBone research in biomechanics
Place of PublicationAmsterdam
PublisherIOS Press
Number of pages228
ISBN (Print)90-5199-327-7
Publication statusPublished - 1997

Publication series

NameStudies in health technology and informatics
ISSN (Print)0926-9630


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