Using dendrimers for the engineering of synthetic vaccines

J.G. Linhardt; D.W.P.M. Lowik; E.W. Meijer; J.C.M. van Hest

Using dendrimers for the engineering of synthetic vaccines

J.G. Linhardt, D.W.P.M. Lowik, E.W. Meijer, J.C.M. van Hest

Research output: Contribution to journal › Article › Academic

Abstract

To study the ability of dendrimer-supported peptides to act as vaccines, four peptides based on the structure of malaria parasite Plasmodium falciparum CS protein were synthesized, modified with a 'click-tail' which will enable insertion of the peptide into a dendrimer via 'clicking' into the interstices between dendrimer end groups. CD spectroscopy of the four peptides showed random coil behavior in aq. soln. in the absence of dendrimer. The four peptides were Ac-P8, (P8 = Gly-Ala-Asn-Pro-Asn-Ala-Ala-Gly-), Click-P8 (Click = -NH(CH2)6NHC(O)NHCH2CO2H), Ac-P8-Click, and Click-P8-Click

Original language	English
Pages (from-to)	799-
Number of pages	1
Journal	Polymer Preprints
Volume	43
Issue number	2
Publication status	Published - 2002
Event	228th ACS National Meeting - Philadelphia, United States Duration: 22 Aug 2004 → 26 Aug 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Using dendrimers for the engineering of synthetic vaccines",

abstract = "To study the ability of dendrimer-supported peptides to act as vaccines, four peptides based on the structure of malaria parasite Plasmodium falciparum CS protein were synthesized, modified with a 'click-tail' which will enable insertion of the peptide into a dendrimer via 'clicking' into the interstices between dendrimer end groups. CD spectroscopy of the four peptides showed random coil behavior in aq. soln. in the absence of dendrimer. The four peptides were Ac-P8, (P8 = Gly-Ala-Asn-Pro-Asn-Ala-Ala-Gly-), Click-P8 (Click = -NH(CH2)6NHC(O)NHCH2CO2H), Ac-P8-Click, and Click-P8-Click",

author = "J.G. Linhardt and D.W.P.M. Lowik and E.W. Meijer and {van Hest}, J.C.M.",

year = "2002",

language = "English",

volume = "43",

pages = "799--",

journal = "Polymer Preprints",

issn = "0032-3934",

number = "2",

note = "228th ACS National Meeting ; Conference date: 22-08-2004 Through 26-08-2004",

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TY - JOUR

T1 - Using dendrimers for the engineering of synthetic vaccines

AU - Linhardt, J.G.

AU - Lowik, D.W.P.M.

AU - Meijer, E.W.

AU - van Hest, J.C.M.

PY - 2002

Y1 - 2002

N2 - To study the ability of dendrimer-supported peptides to act as vaccines, four peptides based on the structure of malaria parasite Plasmodium falciparum CS protein were synthesized, modified with a 'click-tail' which will enable insertion of the peptide into a dendrimer via 'clicking' into the interstices between dendrimer end groups. CD spectroscopy of the four peptides showed random coil behavior in aq. soln. in the absence of dendrimer. The four peptides were Ac-P8, (P8 = Gly-Ala-Asn-Pro-Asn-Ala-Ala-Gly-), Click-P8 (Click = -NH(CH2)6NHC(O)NHCH2CO2H), Ac-P8-Click, and Click-P8-Click

AB - To study the ability of dendrimer-supported peptides to act as vaccines, four peptides based on the structure of malaria parasite Plasmodium falciparum CS protein were synthesized, modified with a 'click-tail' which will enable insertion of the peptide into a dendrimer via 'clicking' into the interstices between dendrimer end groups. CD spectroscopy of the four peptides showed random coil behavior in aq. soln. in the absence of dendrimer. The four peptides were Ac-P8, (P8 = Gly-Ala-Asn-Pro-Asn-Ala-Ala-Gly-), Click-P8 (Click = -NH(CH2)6NHC(O)NHCH2CO2H), Ac-P8-Click, and Click-P8-Click

M3 - Article

SN - 0032-3934

VL - 43

SP - 799-

JO - Polymer Preprints

JF - Polymer Preprints

IS - 2

T2 - 228th ACS National Meeting

Y2 - 22 August 2004 through 26 August 2004

ER -

Using dendrimers for the engineering of synthetic vaccines

Abstract

UN SDGs

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