Ultrasound imaging of the coefficient of nonlinearity

L. Demi, R.J. van Sloun, C. Shan, M. Verweij, M. Mischi

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


Cardiac ablation (CA) is increasingly used to treat atrial fibrillation. However, long-term success is relatively low, and the procedure carries serious risks. To this end, we are developing a β (coefficient of nonlinearity) imaging method that may be employed to perform both tissue characterization and real time temperature estimation to respectively plan, monitor, and execute optimal CA. Starting from a one-dimensional generalized form of the Westervelt equation, we derived an analytical procedure for extracting β which is then further adapted to echo-mode. To evaluate the method performances, in-silico and in-vitro experiments were performed. First, one- to three-dimensional simulations including linear array scanning of three-dimensional objects were obtained with the INCS method. Next, the ULA-OP scanner was used with an Esaote LA332 linear-array to image a phantom consisting of 2-layers obtained as a mixture of oil, gelatin and water. Varying the percentage of oil (β similar to fat), different β values were obtained for the two layers. Both in-silico and in-vitro results show the capability of the method to estimate β variations. Compared to existing methods, the proposed approach provides more stable estimations (spatially) and does not require a special transducer or set-up, being more easily applicable in a clinical setting.
Original languageEnglish
Title of host publicationThe Journal of the Acoustical Society of America
Place of PublicationWashington
PublisherAcoustical Society of America
Publication statusPublished - 2015
EventMeeting of the Acoustical Society of America 2015 - Jacksonville, Florida, United States
Duration: 2 Nov 20156 Nov 2015


ConferenceMeeting of the Acoustical Society of America 2015
CountryUnited States
CityJacksonville, Florida

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    Demi, L., van Sloun, R. J., Shan, C., Verweij, M., & Mischi, M. (2015). Ultrasound imaging of the coefficient of nonlinearity. In The Journal of the Acoustical Society of America (3 ed., Vol. 138, pp. 1883-1883). Acoustical Society of America. https://doi.org/10.1121/1.4933907