With the aim to enable targeted biopsies and focal therapy for prostate cancer (PCa), several ultrasound(US)-based PCa localization methods are emerging. Accurate validation is an essential step towards clinical introduction for any of these methods. Typically, histopathologic analysis of the prostate after excision is used as a gold standard. To enable accurate validation, accurate histology-US registration is required. This registration method should compensate for misalignment between histology slices and US imaging planes, deformation of the prostate after excision, and local deformation at the posterior surface caused by the transrectal US probe. Registration is further complicated by the lack of natural landmarks which are visible in both modalities to assists the registration and the limited slicing resolution of the prostate during preparation for histology. This abstract proposes a 3-dimensional (3D), surface-based, elastic registration method to solve the aforementioned issues.
|Publication status||Published - 2013|