Ultrasound detection of abnormal cerebrovascular morphology in a mouse model of sickle cell disease based on wave reflection

Lindsay S. Cahill (Corresponding author), Jesper Pilmeyer, Lisa X. Yu, Joe Steinman, Gregory M.T. Hare, Andrea Kassner, Christopher K. Macgowan, John G. Sled

Research output: Contribution to journalArticleAcademic

3 Citations (Scopus)

Abstract

Sickle cell disease (SCD) is associated with a high risk of stroke, and affected individuals often have focal brain lesions termed silent cerebral infarcts. The mechanisms leading to these types of injuries are at present poorly understood. Our group has recently demonstrated a non-invasive measurement of cerebrovascular impedance and wave reflection in mice using high-frequency ultrasound in the common carotid artery. To better understand the pathophysiology in SCD, we used this approach in combination with micro-computed tomography to investigate changes in cerebrovascular morphology in the Townes mouse model of SCD. Relative to controls, the SCD mice demonstrated the following: (i) increased carotid artery diameter, blood flow and vessel wall thickness; (ii) elevated pulse wave velocity; (iii) increased reflection coefficient; and (iv) an increase in the total number of vessel segments in the brain. This study highlights the potential for wave reflection to aid the non-invasive clinical assessment of vascular pathology in SCD.
Original languageEnglish
Pages (from-to)3269-3278
Number of pages10
JournalUltrasound in Medicine and Biology
Volume45
Issue number12
DOIs
Publication statusPublished - Sep 2019

Keywords

  • Cerebrovasculature
  • Mouse
  • Pulse wave velocity
  • Sickle cell disease
  • Ultrasound
  • Wave reflection

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