Ultrasonic elasticity determination of 45S5 Bioglass®-based scaffolds: influence of polymer coating and crosslinking treatment

Wei Li; Maria Ioana Pastrama; Yaping Ding; Kai Zheng; Christian Hellmich; Aldo R. Boccaccini

doi:10.1016/j.jmbbm.2014.08.010

Ultrasonic elasticity determination of 45S5 Bioglass^®-based scaffolds: influence of polymer coating and crosslinking treatment

Wei Li
, Maria Ioana Pastrama
, Yaping Ding
, Kai Zheng
, Christian Hellmich
, Aldo R. Boccaccini

Research output: Contribution to journal › Article › Academic › peer-review

24 Citations (Scopus)

Abstract

Highly porous 45S5 Bioglass^®-based scaffolds with interconnected pore structure are promising candidates for bone tissue engineering due to their bioactivity, biocompatibility, osteogenic and angiogenic effects. In the present study, to ensure the mechanical competence of the 45S5 Bioglass^®-based scaffolds, their stiffness was adjusted by applying polymer coatings and further crosslinking treatment. A non-destructive ultrasonic technique was used to determine the stiffness of the scaffolds. The stiffness of uncoated scaffolds was shown to increase by applying polymer coatings, and a further increase was achieved by crosslinking the used polymer coatings. All uncoated and polymer-coated scaffolds were confirmed to exhibit stiffness values in the range of reported values in the literature for cancellous bone. A statistical evaluation of combined multiscale ultrasound-nanoindentation measurements indicated that the stiffness of the coated scaffold is directly dependent on the stiffness of the polymer coating.

Original language	English
Pages (from-to)	85-94
Number of pages	10
Journal	Journal of the Mechanical Behavior of Biomedical Materials
Volume	40
DOIs	https://doi.org/10.1016/j.jmbbm.2014.08.010
Publication status	Published - 1 Dec 2014
Externally published	Yes

Funding

Wei Li would like to acknowledge the European Virtual Institute on Knowledge-based Multifunctional Materials AISBL (KMM-VIN) and China Scholarship Council (CSC) (Grant no. 2011628002 ) for financial support. Christian Hellmich and Maria-Ioana Pastrama are grateful for financial support from the European Research Council , through Project no. 257023 as part of call ERC-2010-StG. The authors thank Dr. Olaf Lahayne, Mr. Krzysztof Luczynski, Ms. Jasmin Hum, and Dr. Menti Goudouri for experimental support.

Keywords

Bioglass
Elasticity
Polymer coating
Scaffold
Ultrasound

Access to Document

10.1016/j.jmbbm.2014.08.010

Cite this

@article{6beca2877d8b4815a9e49582a2ab3492,

title = "Ultrasonic elasticity determination of 45S5 Bioglass{\textregistered}-based scaffolds: influence of polymer coating and crosslinking treatment",

abstract = "Highly porous 45S5 Bioglass{\textregistered}-based scaffolds with interconnected pore structure are promising candidates for bone tissue engineering due to their bioactivity, biocompatibility, osteogenic and angiogenic effects. In the present study, to ensure the mechanical competence of the 45S5 Bioglass{\textregistered}-based scaffolds, their stiffness was adjusted by applying polymer coatings and further crosslinking treatment. A non-destructive ultrasonic technique was used to determine the stiffness of the scaffolds. The stiffness of uncoated scaffolds was shown to increase by applying polymer coatings, and a further increase was achieved by crosslinking the used polymer coatings. All uncoated and polymer-coated scaffolds were confirmed to exhibit stiffness values in the range of reported values in the literature for cancellous bone. A statistical evaluation of combined multiscale ultrasound-nanoindentation measurements indicated that the stiffness of the coated scaffold is directly dependent on the stiffness of the polymer coating.",

keywords = "Bioglass, Elasticity, Polymer coating, Scaffold, Ultrasound",

author = "Wei Li and Pastrama, \{Maria Ioana\} and Yaping Ding and Kai Zheng and Christian Hellmich and Boccaccini, \{Aldo R.\}",

year = "2014",

month = dec,

day = "1",

doi = "10.1016/j.jmbbm.2014.08.010",

language = "English",

volume = "40",

pages = "85--94",

journal = "Journal of the Mechanical Behavior of Biomedical Materials",

issn = "1751-6161",

publisher = "Elsevier",

}

TY - JOUR

T1 - Ultrasonic elasticity determination of 45S5 Bioglass®-based scaffolds

T2 - influence of polymer coating and crosslinking treatment

AU - Li, Wei

AU - Pastrama, Maria Ioana

AU - Ding, Yaping

AU - Zheng, Kai

AU - Hellmich, Christian

AU - Boccaccini, Aldo R.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Highly porous 45S5 Bioglass®-based scaffolds with interconnected pore structure are promising candidates for bone tissue engineering due to their bioactivity, biocompatibility, osteogenic and angiogenic effects. In the present study, to ensure the mechanical competence of the 45S5 Bioglass®-based scaffolds, their stiffness was adjusted by applying polymer coatings and further crosslinking treatment. A non-destructive ultrasonic technique was used to determine the stiffness of the scaffolds. The stiffness of uncoated scaffolds was shown to increase by applying polymer coatings, and a further increase was achieved by crosslinking the used polymer coatings. All uncoated and polymer-coated scaffolds were confirmed to exhibit stiffness values in the range of reported values in the literature for cancellous bone. A statistical evaluation of combined multiscale ultrasound-nanoindentation measurements indicated that the stiffness of the coated scaffold is directly dependent on the stiffness of the polymer coating.

AB - Highly porous 45S5 Bioglass®-based scaffolds with interconnected pore structure are promising candidates for bone tissue engineering due to their bioactivity, biocompatibility, osteogenic and angiogenic effects. In the present study, to ensure the mechanical competence of the 45S5 Bioglass®-based scaffolds, their stiffness was adjusted by applying polymer coatings and further crosslinking treatment. A non-destructive ultrasonic technique was used to determine the stiffness of the scaffolds. The stiffness of uncoated scaffolds was shown to increase by applying polymer coatings, and a further increase was achieved by crosslinking the used polymer coatings. All uncoated and polymer-coated scaffolds were confirmed to exhibit stiffness values in the range of reported values in the literature for cancellous bone. A statistical evaluation of combined multiscale ultrasound-nanoindentation measurements indicated that the stiffness of the coated scaffold is directly dependent on the stiffness of the polymer coating.

KW - Bioglass

KW - Elasticity

KW - Polymer coating

KW - Scaffold

KW - Ultrasound

UR - https://www.scopus.com/pages/publications/84907556244

U2 - 10.1016/j.jmbbm.2014.08.010

DO - 10.1016/j.jmbbm.2014.08.010

M3 - Article

C2 - 25215906

AN - SCOPUS:84907556244

SN - 1751-6161

VL - 40

SP - 85

EP - 94

JO - Journal of the Mechanical Behavior of Biomedical Materials

JF - Journal of the Mechanical Behavior of Biomedical Materials

ER -