TY - JOUR
T1 - Ultrasonic elasticity determination of 45S5 Bioglass®-based scaffolds
T2 - influence of polymer coating and crosslinking treatment
AU - Li, Wei
AU - Pastrama, Maria Ioana
AU - Ding, Yaping
AU - Zheng, Kai
AU - Hellmich, Christian
AU - Boccaccini, Aldo R.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Highly porous 45S5 Bioglass®-based scaffolds with interconnected pore structure are promising candidates for bone tissue engineering due to their bioactivity, biocompatibility, osteogenic and angiogenic effects. In the present study, to ensure the mechanical competence of the 45S5 Bioglass®-based scaffolds, their stiffness was adjusted by applying polymer coatings and further crosslinking treatment. A non-destructive ultrasonic technique was used to determine the stiffness of the scaffolds. The stiffness of uncoated scaffolds was shown to increase by applying polymer coatings, and a further increase was achieved by crosslinking the used polymer coatings. All uncoated and polymer-coated scaffolds were confirmed to exhibit stiffness values in the range of reported values in the literature for cancellous bone. A statistical evaluation of combined multiscale ultrasound-nanoindentation measurements indicated that the stiffness of the coated scaffold is directly dependent on the stiffness of the polymer coating.
AB - Highly porous 45S5 Bioglass®-based scaffolds with interconnected pore structure are promising candidates for bone tissue engineering due to their bioactivity, biocompatibility, osteogenic and angiogenic effects. In the present study, to ensure the mechanical competence of the 45S5 Bioglass®-based scaffolds, their stiffness was adjusted by applying polymer coatings and further crosslinking treatment. A non-destructive ultrasonic technique was used to determine the stiffness of the scaffolds. The stiffness of uncoated scaffolds was shown to increase by applying polymer coatings, and a further increase was achieved by crosslinking the used polymer coatings. All uncoated and polymer-coated scaffolds were confirmed to exhibit stiffness values in the range of reported values in the literature for cancellous bone. A statistical evaluation of combined multiscale ultrasound-nanoindentation measurements indicated that the stiffness of the coated scaffold is directly dependent on the stiffness of the polymer coating.
KW - Bioglass
KW - Elasticity
KW - Polymer coating
KW - Scaffold
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=84907556244&partnerID=8YFLogxK
U2 - 10.1016/j.jmbbm.2014.08.010
DO - 10.1016/j.jmbbm.2014.08.010
M3 - Article
C2 - 25215906
AN - SCOPUS:84907556244
SN - 1751-6161
VL - 40
SP - 85
EP - 94
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
ER -