Two-voxel localization sequence for in vivo two-dimensional homonuclear correlation spectroscopy

F. Delmas, J.C. Beloeil, B.P.J. Sanden, van der, K. Nicolaij, B. Gillet

    Research output: Contribution to journalArticleAcademicpeer-review

    11 Citations (Scopus)


    The combination of localized 2D 1H MR correlation spectroscopy and Hadamard encoding allows the simultaneous acquisition of multiple volumes of interest without an increase in the experimental duration, compared to single-voxel acquisition. In the present study, 2D correlation spectra were acquired simultaneously within 20 to 40 min in two voxels located in each hemisphere of the rat brain. An intervoxel distance of 20% of the voxel size was sufficient to limit spatial contamination. The following cerebral metabolites gave detectable crosspeaks: N-acetylaspartate, the glutamate/glutamine pool, aspartate, phosphoethanolamine, glucose, glutathione, taurine, myo-inositols, lactate, threonine, ¿-aminobutyric acid, and alanine. Most of the metabolites were measured without contamination of other resonances. two-dimensional correlation 1H MRS
    Original languageEnglish
    Pages (from-to)119-125
    JournalJournal of Magnetic Resonance
    Issue number1
    Publication statusPublished - 2001


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