Two new radiopaque polymeric biomaterials

M.A.B. Kruft, A. Benzina, F.W.H.M. Bär, F.H. Veen, van der, C.W.M. Bastiaansen, R. Blezer, T. Lindhout, L.H. Koole

    Research output: Contribution to journalArticleAcademicpeer-review

    47 Citations (Scopus)
    26 Downloads (Pure)

    Abstract

    Two new polymeric materials (polymers A and B) contg. covalently bound iodine were prepd. These polymers were evaluated with respect to their possible use as radiopaque implant biomaterials-i.e., materials that are visible in a noninvasive manner using routine X-ray absorption imaging techniques. Polymer A is a copolymer of Me methacrylate (MMA) and 4-IC6H4O2CCMe:CH2 (I) (80 and 20 mol%, resp.). Polymer B was prepd. from MMA, I, and 2-hydroxyethyl methacrylate (HEMA) (mol ratio 65:20:15, resp.). I was synthesized from 4-iodophenol and methacryloyl chloride. The resulting polymers were characterized with GPC, DSC, NMR, and by measuring both the advancing and receding contact angles. Thrombogenicity of the polymers was detd. by an in vitro thrombin generation test procedure. The max. concn. of free thrombin was 76 +- 1 nM for polymer A, and 64 +- 3 nM for polymer B. The lag times (i.e., time onset of thrombin generation) were 392 s for polymer A and 553 s for polymer B. For PVC-T, which is known as a passive material, a lag time of 583 s was found. This indicates that polymer B is comparable to PVC-T, and more passive than polymer A. Polymer A exhibited minor activation of platelets. Polymer B did not induce platelet activation at all. The polymers exhibited, even as fibers with a diam. of ca. 0.3 mm, good radiopacity with routine imaging X-ray techniques in the clinic. It is argued that polymers A and B-which actually represent a whole family of radiopaque polymeric biomaterials-exhibit promising properties with respect to applications as construction materials for a new generation of endovascular stents. [on SciFinder (R)]
    Original languageEnglish
    Pages (from-to)1259-1266
    JournalJournal of Biomedical Materials Research
    Volume28
    Issue number11
    DOIs
    Publication statusPublished - 1994

    Fingerprint

    Biocompatible Materials
    Biomaterials
    Polymers
    Thrombin
    Methacrylates
    Platelets
    Polyvinyl Chloride
    Polyvinyl chlorides
    Chemical activation
    Imaging techniques
    Stents
    X ray absorption
    Iodine
    Contact angle

    Cite this

    Kruft, M. A. B., Benzina, A., Bär, F. W. H. M., Veen, van der, F. H., Bastiaansen, C. W. M., Blezer, R., ... Koole, L. H. (1994). Two new radiopaque polymeric biomaterials. Journal of Biomedical Materials Research, 28(11), 1259-1266. https://doi.org/10.1002/jbm.820281103
    Kruft, M.A.B. ; Benzina, A. ; Bär, F.W.H.M. ; Veen, van der, F.H. ; Bastiaansen, C.W.M. ; Blezer, R. ; Lindhout, T. ; Koole, L.H. / Two new radiopaque polymeric biomaterials. In: Journal of Biomedical Materials Research. 1994 ; Vol. 28, No. 11. pp. 1259-1266.
    @article{c03e63c61f35499eb883194e5e14164c,
    title = "Two new radiopaque polymeric biomaterials",
    abstract = "Two new polymeric materials (polymers A and B) contg. covalently bound iodine were prepd. These polymers were evaluated with respect to their possible use as radiopaque implant biomaterials-i.e., materials that are visible in a noninvasive manner using routine X-ray absorption imaging techniques. Polymer A is a copolymer of Me methacrylate (MMA) and 4-IC6H4O2CCMe:CH2 (I) (80 and 20 mol{\%}, resp.). Polymer B was prepd. from MMA, I, and 2-hydroxyethyl methacrylate (HEMA) (mol ratio 65:20:15, resp.). I was synthesized from 4-iodophenol and methacryloyl chloride. The resulting polymers were characterized with GPC, DSC, NMR, and by measuring both the advancing and receding contact angles. Thrombogenicity of the polymers was detd. by an in vitro thrombin generation test procedure. The max. concn. of free thrombin was 76 +- 1 nM for polymer A, and 64 +- 3 nM for polymer B. The lag times (i.e., time onset of thrombin generation) were 392 s for polymer A and 553 s for polymer B. For PVC-T, which is known as a passive material, a lag time of 583 s was found. This indicates that polymer B is comparable to PVC-T, and more passive than polymer A. Polymer A exhibited minor activation of platelets. Polymer B did not induce platelet activation at all. The polymers exhibited, even as fibers with a diam. of ca. 0.3 mm, good radiopacity with routine imaging X-ray techniques in the clinic. It is argued that polymers A and B-which actually represent a whole family of radiopaque polymeric biomaterials-exhibit promising properties with respect to applications as construction materials for a new generation of endovascular stents. [on SciFinder (R)]",
    author = "M.A.B. Kruft and A. Benzina and F.W.H.M. B{\"a}r and {Veen, van der}, F.H. and C.W.M. Bastiaansen and R. Blezer and T. Lindhout and L.H. Koole",
    year = "1994",
    doi = "10.1002/jbm.820281103",
    language = "English",
    volume = "28",
    pages = "1259--1266",
    journal = "Journal of Biomedical Materials Research",
    issn = "0021-9304",
    publisher = "Heterocorporation",
    number = "11",

    }

    Kruft, MAB, Benzina, A, Bär, FWHM, Veen, van der, FH, Bastiaansen, CWM, Blezer, R, Lindhout, T & Koole, LH 1994, 'Two new radiopaque polymeric biomaterials', Journal of Biomedical Materials Research, vol. 28, no. 11, pp. 1259-1266. https://doi.org/10.1002/jbm.820281103

    Two new radiopaque polymeric biomaterials. / Kruft, M.A.B.; Benzina, A.; Bär, F.W.H.M.; Veen, van der, F.H.; Bastiaansen, C.W.M.; Blezer, R.; Lindhout, T.; Koole, L.H.

    In: Journal of Biomedical Materials Research, Vol. 28, No. 11, 1994, p. 1259-1266.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Two new radiopaque polymeric biomaterials

    AU - Kruft, M.A.B.

    AU - Benzina, A.

    AU - Bär, F.W.H.M.

    AU - Veen, van der, F.H.

    AU - Bastiaansen, C.W.M.

    AU - Blezer, R.

    AU - Lindhout, T.

    AU - Koole, L.H.

    PY - 1994

    Y1 - 1994

    N2 - Two new polymeric materials (polymers A and B) contg. covalently bound iodine were prepd. These polymers were evaluated with respect to their possible use as radiopaque implant biomaterials-i.e., materials that are visible in a noninvasive manner using routine X-ray absorption imaging techniques. Polymer A is a copolymer of Me methacrylate (MMA) and 4-IC6H4O2CCMe:CH2 (I) (80 and 20 mol%, resp.). Polymer B was prepd. from MMA, I, and 2-hydroxyethyl methacrylate (HEMA) (mol ratio 65:20:15, resp.). I was synthesized from 4-iodophenol and methacryloyl chloride. The resulting polymers were characterized with GPC, DSC, NMR, and by measuring both the advancing and receding contact angles. Thrombogenicity of the polymers was detd. by an in vitro thrombin generation test procedure. The max. concn. of free thrombin was 76 +- 1 nM for polymer A, and 64 +- 3 nM for polymer B. The lag times (i.e., time onset of thrombin generation) were 392 s for polymer A and 553 s for polymer B. For PVC-T, which is known as a passive material, a lag time of 583 s was found. This indicates that polymer B is comparable to PVC-T, and more passive than polymer A. Polymer A exhibited minor activation of platelets. Polymer B did not induce platelet activation at all. The polymers exhibited, even as fibers with a diam. of ca. 0.3 mm, good radiopacity with routine imaging X-ray techniques in the clinic. It is argued that polymers A and B-which actually represent a whole family of radiopaque polymeric biomaterials-exhibit promising properties with respect to applications as construction materials for a new generation of endovascular stents. [on SciFinder (R)]

    AB - Two new polymeric materials (polymers A and B) contg. covalently bound iodine were prepd. These polymers were evaluated with respect to their possible use as radiopaque implant biomaterials-i.e., materials that are visible in a noninvasive manner using routine X-ray absorption imaging techniques. Polymer A is a copolymer of Me methacrylate (MMA) and 4-IC6H4O2CCMe:CH2 (I) (80 and 20 mol%, resp.). Polymer B was prepd. from MMA, I, and 2-hydroxyethyl methacrylate (HEMA) (mol ratio 65:20:15, resp.). I was synthesized from 4-iodophenol and methacryloyl chloride. The resulting polymers were characterized with GPC, DSC, NMR, and by measuring both the advancing and receding contact angles. Thrombogenicity of the polymers was detd. by an in vitro thrombin generation test procedure. The max. concn. of free thrombin was 76 +- 1 nM for polymer A, and 64 +- 3 nM for polymer B. The lag times (i.e., time onset of thrombin generation) were 392 s for polymer A and 553 s for polymer B. For PVC-T, which is known as a passive material, a lag time of 583 s was found. This indicates that polymer B is comparable to PVC-T, and more passive than polymer A. Polymer A exhibited minor activation of platelets. Polymer B did not induce platelet activation at all. The polymers exhibited, even as fibers with a diam. of ca. 0.3 mm, good radiopacity with routine imaging X-ray techniques in the clinic. It is argued that polymers A and B-which actually represent a whole family of radiopaque polymeric biomaterials-exhibit promising properties with respect to applications as construction materials for a new generation of endovascular stents. [on SciFinder (R)]

    U2 - 10.1002/jbm.820281103

    DO - 10.1002/jbm.820281103

    M3 - Article

    VL - 28

    SP - 1259

    EP - 1266

    JO - Journal of Biomedical Materials Research

    JF - Journal of Biomedical Materials Research

    SN - 0021-9304

    IS - 11

    ER -

    Kruft MAB, Benzina A, Bär FWHM, Veen, van der FH, Bastiaansen CWM, Blezer R et al. Two new radiopaque polymeric biomaterials. Journal of Biomedical Materials Research. 1994;28(11):1259-1266. https://doi.org/10.1002/jbm.820281103