Tuning of column polarity and peak position in complex chromatograms by means of coupled capillary columns

T. Toth, H. Cruchten, van, J.A. Rijks

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Abstract

A method is described that allows a predictable reproducible continuous variation of column polarity. It permits a controlled peak shift of individual peaks in chromatograms of complex samples by means of coupled (tandem) capillary columns. The columns which have a different polarity are coupled via a "Deans type" switching device in between the columns. Considering the effects of the nature of the stationary phase, film thickness, column length, column temperature and pressure drop across the coupled columns, it appears that a required tailor-made polarity can be calculated and achieved with a high degree of reliability. The actual and predicted column polarity and peak position or peak shift of an individual peak are in surprisingly good agreement (<0.5 Iu).
Original languageEnglish
Title of host publicationProceedings of the Sixth International symposium on capillary chromatography, Riva del Garda, 14-16 May 1985
EditorsP Sandra, W. Bertsch, P. Sandra
Place of PublicationHeidelberg
PublisherHuethig
Pages769-773
Publication statusPublished - 1985
Event6th International Symposium on Capillary Chromatography, May 14-16 1985, Riva del Garda, Italy - Riva del Garda, Italy
Duration: 14 May 198516 May 1985

Conference

Conference6th International Symposium on Capillary Chromatography, May 14-16 1985, Riva del Garda, Italy
CountryItaly
CityRiva del Garda
Period14/05/8516/05/85

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