Tumoricidal activity of human dendritic cells

J. Tel; S. Anguille; C.E.J. Waterborg; E.L. Smits; C.G. Figdor; I.J.M. de Vries

doi:10.1016/j.it.2013.10.007

Tumoricidal activity of human dendritic cells

J. Tel, S. Anguille, C.E.J. Waterborg, E.L. Smits, C.G. Figdor, I.J.M. de Vries

Research output: Contribution to journal › Article › Academic › peer-review

62 Citations (Scopus)

Abstract

Dendritic cells (DCs) are a family of professional antigen-presenting cells (APCs) that are able to initiate innate and adaptive immune responses against pathogens and tumor cells. The DC family is heterogeneous and is classically divided into two main subsets, each with its unique phenotypic and functional characteristics: myeloid DCs (mDCs) and plasmacytoid DCs (pDCs). Recent results have provided intriguing evidence that both DC subsets can also function as direct cytotoxic effector cells; in particular, against cancer cells. In this review, we delve into this understudied function of human DCs and discuss why these so-called killer DCs might become important tools in future cancer immunotherapies.

Original language	English
Pages (from-to)	38-46
Number of pages	9
Journal	Trends in Immunology
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.it.2013.10.007
Publication status	Published - Jan 2014
Externally published	Yes

Keywords

Adaptive Immunity
Animals
Cytokines
Cytotoxicity, Immunologic
Dendritic Cells
Humans
Immunotherapy
Neoplasms
Phenotype
Journal Article
Research Support, Non-U.S. Gov't
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.it.2013.10.007

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title = "Tumoricidal activity of human dendritic cells",

abstract = "Dendritic cells (DCs) are a family of professional antigen-presenting cells (APCs) that are able to initiate innate and adaptive immune responses against pathogens and tumor cells. The DC family is heterogeneous and is classically divided into two main subsets, each with its unique phenotypic and functional characteristics: myeloid DCs (mDCs) and plasmacytoid DCs (pDCs). Recent results have provided intriguing evidence that both DC subsets can also function as direct cytotoxic effector cells; in particular, against cancer cells. In this review, we delve into this understudied function of human DCs and discuss why these so-called killer DCs might become important tools in future cancer immunotherapies.",

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author = "J. Tel and S. Anguille and C.E.J. Waterborg and E.L. Smits and C.G. Figdor and {de Vries}, I.J.M.",

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month = jan,

doi = "10.1016/j.it.2013.10.007",

language = "English",

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T1 - Tumoricidal activity of human dendritic cells

AU - Tel, J.

AU - Anguille, S.

AU - Waterborg, C.E.J.

AU - Smits, E.L.

AU - Figdor, C.G.

AU - de Vries, I.J.M.

PY - 2014/1

Y1 - 2014/1

N2 - Dendritic cells (DCs) are a family of professional antigen-presenting cells (APCs) that are able to initiate innate and adaptive immune responses against pathogens and tumor cells. The DC family is heterogeneous and is classically divided into two main subsets, each with its unique phenotypic and functional characteristics: myeloid DCs (mDCs) and plasmacytoid DCs (pDCs). Recent results have provided intriguing evidence that both DC subsets can also function as direct cytotoxic effector cells; in particular, against cancer cells. In this review, we delve into this understudied function of human DCs and discuss why these so-called killer DCs might become important tools in future cancer immunotherapies.

AB - Dendritic cells (DCs) are a family of professional antigen-presenting cells (APCs) that are able to initiate innate and adaptive immune responses against pathogens and tumor cells. The DC family is heterogeneous and is classically divided into two main subsets, each with its unique phenotypic and functional characteristics: myeloid DCs (mDCs) and plasmacytoid DCs (pDCs). Recent results have provided intriguing evidence that both DC subsets can also function as direct cytotoxic effector cells; in particular, against cancer cells. In this review, we delve into this understudied function of human DCs and discuss why these so-called killer DCs might become important tools in future cancer immunotherapies.

KW - Adaptive Immunity

KW - Animals

KW - Cytokines

KW - Cytotoxicity, Immunologic

KW - Dendritic Cells

KW - Humans

KW - Immunotherapy

KW - Neoplasms

KW - Phenotype

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1016/j.it.2013.10.007

DO - 10.1016/j.it.2013.10.007

M3 - Article

C2 - 24262387

SN - 1471-4906

VL - 35

SP - 38

EP - 46

JO - Trends in Immunology

JF - Trends in Immunology

IS - 1

ER -

Tumoricidal activity of human dendritic cells

Abstract

Keywords

UN SDGs

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