Tumoricidal activity of human dendritic cells

J. Tel, S. Anguille, C.E.J. Waterborg, E.L. Smits, C.G. Figdor, I.J.M. de Vries

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Scopus)

Abstract

Dendritic cells (DCs) are a family of professional antigen-presenting cells (APCs) that are able to initiate innate and adaptive immune responses against pathogens and tumor cells. The DC family is heterogeneous and is classically divided into two main subsets, each with its unique phenotypic and functional characteristics: myeloid DCs (mDCs) and plasmacytoid DCs (pDCs). Recent results have provided intriguing evidence that both DC subsets can also function as direct cytotoxic effector cells; in particular, against cancer cells. In this review, we delve into this understudied function of human DCs and discuss why these so-called killer DCs might become important tools in future cancer immunotherapies.

Original languageEnglish
Pages (from-to)38-46
Number of pages9
JournalTrends in Immunology
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2014
Externally publishedYes

Keywords

  • Adaptive Immunity
  • Animals
  • Cytokines
  • Cytotoxicity, Immunologic
  • Dendritic Cells
  • Humans
  • Immunotherapy
  • Neoplasms
  • Phenotype
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

Fingerprint Dive into the research topics of 'Tumoricidal activity of human dendritic cells'. Together they form a unique fingerprint.

Cite this