Traumatic Brain Injury at Multiple Length Scales: Relating Diffuse Axonal Injury to Discrete Axonal Impairment

R.J.H. Cloots, J.A.W. Dommelen, van, S. Kleiven, M.G.D. Geers

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

11 Citations (Scopus)

Abstract

The length scales involved in the development of diffuse axonal injury, typically range from thehead level (i.e., mechanical loading) to the cellular level, where discrete axonal injuries are located nearinclusions. The aim is to investigate the local axonal strains near an inclusion in relation to the tissue level strains of the brain stem during mechanical loading of the head and the resulting orientation dependence of tissue level injury criteria. For this, a multi-scale FE approach is adopted. The results show that the axonal strains cannot be trivially correlated to the tissue strain without taking into account the axonal orientations, which indicates that the heterogeneities at the cellular level play an important role in brain injury and reliable predictions of it.
Original languageEnglish
Title of host publicationProceedings of the International Conference on the Biomechanics of Impact, IRCOBI
Place of PublicationGermany, Hannover
Pages119-130
Publication statusPublished - 2010

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    Cloots, R. J. H., Dommelen, van, J. A. W., Kleiven, S., & Geers, M. G. D. (2010). Traumatic Brain Injury at Multiple Length Scales: Relating Diffuse Axonal Injury to Discrete Axonal Impairment. In Proceedings of the International Conference on the Biomechanics of Impact, IRCOBI (pp. 119-130). Germany, Hannover.