TY - JOUR
T1 - Transport of guest molecules by unimolecular micelles evidenced in analytical ultracentrifugation experiments
AU - Rasa, M.V
AU - Meier, M.A.R.
AU - Schubert, U.S.
PY - 2007
Y1 - 2007
N2 - The ability of star-shaped, block copolymer-based unimolecular micelles to encapsulate and transport guest molecules was studied. Analytical ultracentrifugation studies clearly showed that methyl-orange guest molecules could be encapsulated and transported, together with unimolecular micelles consisting of 5-arm, star-shaped block copolymers with a poly(ethylene glycol) core and a poly(-caprolactone) corona. Sedimentation-velocity and equilibrium measurements were performed to determine the sedimentation coefficients, molar masses, and diffusion coefficients of the loaded, unimolecular micelles. It was observed that the transport of guest molecules by unimolecular micelles was a function of the molecular weight of the star-shaped block copolymers and therefore also of their size.
AB - The ability of star-shaped, block copolymer-based unimolecular micelles to encapsulate and transport guest molecules was studied. Analytical ultracentrifugation studies clearly showed that methyl-orange guest molecules could be encapsulated and transported, together with unimolecular micelles consisting of 5-arm, star-shaped block copolymers with a poly(ethylene glycol) core and a poly(-caprolactone) corona. Sedimentation-velocity and equilibrium measurements were performed to determine the sedimentation coefficients, molar masses, and diffusion coefficients of the loaded, unimolecular micelles. It was observed that the transport of guest molecules by unimolecular micelles was a function of the molecular weight of the star-shaped block copolymers and therefore also of their size.
U2 - 10.1002/marc.200700115
DO - 10.1002/marc.200700115
M3 - Article
VL - 28
SP - 1429
EP - 1433
JO - Macromolecular Rapid Communications
JF - Macromolecular Rapid Communications
SN - 1022-1336
IS - 13
ER -