Transplantation of allogeneic PW1pos/Pax7neg interstitial cells enhance endogenous repair of injured porcine skeletal muscle

F.C. Lewis, B.J. Cottle, V. Shone, G. Marazzi, D. Sassoon, C.C.S. Tseng, P.Y.W. Dankers, S.A.J. Chamuleau, B. Nadal-Ginard, G.M. Ellison-Hughes

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    2 Citations (Scopus)
    82 Downloads (Pure)

    Abstract

    Skeletal muscle-derived PW1pos/Pax7neg interstitial cells (PICs) express and secrete a multitude of proregenerative growth factors and cytokines. Utilizing a porcine preclinical skeletal muscle injury model, delivery of allogeneic porcine PICs (pPICs) significantly improved and accelerated myofiber regeneration and neocapillarization, compared with saline vehicle control-treated muscles. Allogeneic pPICs did not contribute to new myofibers or capillaries and were eliminated by the host immune system. In conclusion, allogeneic pPIC transplantation stimulated the endogenous stem cell pool to bring about enhanced autologous skeletal muscle repair and regeneration. This allogeneic cell approach is considered a cost-effective, easy to apply, and readily available regenerative therapeutic strategy.

    Original languageEnglish
    Pages (from-to)717-736
    Number of pages20
    JournalJACC: Basic to Translational Science
    Volume2
    Issue number6
    DOIs
    Publication statusPublished - 1 Dec 2017

    Keywords

    • allogeneic progenitor cells
    • growth factors
    • PICs
    • porcine preclinical model
    • regeneration
    • skeletal muscle

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