Transcatheter-delivered expandable bioresorbable polymeric graft with stenting capacity induces vascular regeneration

Renee Duijvelshoff; Maria S. Cabrera; Bart Sanders; Sylvia Dekker; Anthal I.P.M. Smits; Frank P.T. Baaijens; Carlijn V.C. Bouten

doi:10.1016/j.jacbts.2020.09.005

Transcatheter-delivered expandable bioresorbable polymeric graft with stenting capacity induces vascular regeneration

Renee Duijvelshoff
, Maria S. Cabrera
, Bart Sanders
, Sylvia Dekker
, Anthal I.P.M. Smits
, Frank P.T. Baaijens
, Carlijn V.C. Bouten (Corresponding author)

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

As the next step in the translation of vascular tissue engineering, this study uniquely combines transcatheter delivery and in situ tissue regeneration using a novel bioresorbable electrospun polymer graft that can be implanted minimally invasively. Once delivered inside a small-diameter vessel, the electrospun microstructure supports the vessel wall, facilitates cellular infiltration, and guides organized tissue formation.

Original language	English
Pages (from-to)	1095-1110
Number of pages	16
Journal	JACC: Basic to Translational Science
Volume	5
Issue number	11
DOIs	https://doi.org/10.1016/j.jacbts.2020.09.005
Publication status	Published - Nov 2020

Funding

The authors thank Dr. Serena Buscone and Arturo Lichauco, MSc, (Department of Biomedical Engineering, Eindhoven University of Technology) for assistance and expert advice on histology, and Prof. Dr. Patricia Dankers for critical analysis of the manuscript. This work was funded by a grant from the Dutch government to the Netherlands Institute for Regenerative Medicine (grant FES0908). The authors gratefully acknowledge funding from the Ministry of Education, Culture and Science for the Gravitation Program 024.003.103 “Materials Driven Regeneration.” Stentit provided funding to this study through a soft loan provided by the Dutch government (STW Take-Off Phase 2, project 15672). Drs. Bart Sanders and Maria Cabrera are founders and shareholders of Stentit B.V. Drs. Bart Sanders, Maria S. Cabrera, and Frank P.T. Baaijens are the holders of a patent related to the presented graft technology. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Funders
Eindhoven University of Technology

Keywords

elastin
regeneration
tissue engineering
transcatheter delivery
vascular graft

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10.1016/j.jacbts.2020.09.005Licence: CC BY-NC-ND

Cite this

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title = "Transcatheter-delivered expandable bioresorbable polymeric graft with stenting capacity induces vascular regeneration",

abstract = "As the next step in the translation of vascular tissue engineering, this study uniquely combines transcatheter delivery and in situ tissue regeneration using a novel bioresorbable electrospun polymer graft that can be implanted minimally invasively. Once delivered inside a small-diameter vessel, the electrospun microstructure supports the vessel wall, facilitates cellular infiltration, and guides organized tissue formation.",

keywords = "elastin, regeneration, tissue engineering, transcatheter delivery, vascular graft",

author = "Renee Duijvelshoff and Cabrera, \{Maria S.\} and Bart Sanders and Sylvia Dekker and Smits, \{Anthal I.P.M.\} and Baaijens, \{Frank P.T.\} and Bouten, \{Carlijn V.C.\}",

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AU - Duijvelshoff, Renee

AU - Cabrera, Maria S.

AU - Sanders, Bart

AU - Dekker, Sylvia

AU - Smits, Anthal I.P.M.

AU - Baaijens, Frank P.T.

AU - Bouten, Carlijn V.C.

PY - 2020/11

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N2 - As the next step in the translation of vascular tissue engineering, this study uniquely combines transcatheter delivery and in situ tissue regeneration using a novel bioresorbable electrospun polymer graft that can be implanted minimally invasively. Once delivered inside a small-diameter vessel, the electrospun microstructure supports the vessel wall, facilitates cellular infiltration, and guides organized tissue formation.

AB - As the next step in the translation of vascular tissue engineering, this study uniquely combines transcatheter delivery and in situ tissue regeneration using a novel bioresorbable electrospun polymer graft that can be implanted minimally invasively. Once delivered inside a small-diameter vessel, the electrospun microstructure supports the vessel wall, facilitates cellular infiltration, and guides organized tissue formation.

KW - elastin

KW - regeneration

KW - tissue engineering

KW - transcatheter delivery

KW - vascular graft

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ER -

Transcatheter-delivered expandable bioresorbable polymeric graft with stenting capacity induces vascular regeneration

Abstract

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Keywords

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One step closer to regenerative heart valves and stents

Cite this

Transcatheter-delivered expandable bioresorbable polymeric graft with stenting capacity induces vascular regeneration

Abstract

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Press/Media

One step closer to regenerative heart valves and stents

Cite this