Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Maziar Divangahi (Corresponding author), Peter Aaby, Shabaana Abdul Khader, Luis B. Barreiro, Siroon Bekkering, Triantafyllos Chavakis, Reinout van Crevel, Nigel Curtis, Andrew R. DiNardo, Jorge Dominguez-Andres, Raphael Duivenwoorden, Stephanie Fanucchi, Zahi Fayad, Elaine Fuchs, Melanie Hamon, Kate L. Jeffrey, Nargis Khan, Leo A.B. Joosten, Eva Kaufmann, Eicke LatzGiuseppe Matarese, Jos W.M. van der Meer, Musa Mhlanga, Simone J.C.F.M. Moorlag, Willem J.M. Mulder, Shruti Naik, Boris Novakovic, Luke O’Neill, Jordi Ochando, Keiko Ozato, Niels P. Riksen, Robert Sauerwein, Edward R. Sherwood, Andreas Schlitzer, Joachim L. Schultze, Michael H. Sieweke, Christine Stabell Benn, Henk Stunnenberg, Joseph Sun, Frank L. van de Veerdonk, Sebastian Weis, David L. Williams, Ramnik Xavier, Mihai G. Netea (Corresponding author)

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

320 Citations (Scopus)

Abstract

The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.

Original languageEnglish
Pages (from-to)2-6
Number of pages5
JournalNature Immunology
Volume22
Issue number1
DOIs
Publication statusPublished - 1 Jan 2021

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